This file is indexed.

/usr/share/zope/Products/ReplaceSupport/HANDLERS.txt is in zope-replacesupport 1.0.3-6.

This file is owned by root:root, with mode 0o644.

The actual contents of the file can be viewed below.

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You can define your own replace handlers by creating modules
in the Handlers subdirectory. Such modules must contain a class 
derived from ReplaceHandler.

See the default handlers for examples and the ReplaceHandler.py 
module for the base class & some explanations

If you implement additional handlers please send them to me, so I 
can include them in the distribution.