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// --------------------------------------------------------------------------
//                   OpenMS -- Open-Source Mass Spectrometry
// --------------------------------------------------------------------------
// Copyright The OpenMS Team -- Eberhard Karls University Tuebingen,
// ETH Zurich, and Freie Universitaet Berlin 2002-2013.
// 
// This software is released under a three-clause BSD license:
//  * Redistributions of source code must retain the above copyright
//    notice, this list of conditions and the following disclaimer.
//  * Redistributions in binary form must reproduce the above copyright
//    notice, this list of conditions and the following disclaimer in the
//    documentation and/or other materials provided with the distribution.
//  * Neither the name of any author or any participating institution
//    may be used to endorse or promote products derived from this software
//    without specific prior written permission.
// For a full list of authors, refer to the file AUTHORS.
// --------------------------------------------------------------------------
// THIS SOFTWARE IS PROVIDED BY THE COPYRIGHT HOLDERS AND CONTRIBUTORS "AS IS"
// AND ANY EXPRESS OR IMPLIED WARRANTIES, INCLUDING, BUT NOT LIMITED TO, THE
// IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE
// ARE DISCLAIMED. IN NO EVENT SHALL ANY OF THE AUTHORS OR THE CONTRIBUTING
// INSTITUTIONS BE LIABLE FOR ANY DIRECT, INDIRECT, INCIDENTAL, SPECIAL,
// EXEMPLARY, OR CONSEQUENTIAL DAMAGES (INCLUDING, BUT NOT LIMITED TO,
// PROCUREMENT OF SUBSTITUTE GOODS OR SERVICES; LOSS OF USE, DATA, OR PROFITS;
// OR BUSINESS INTERRUPTION) HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY,
// WHETHER IN CONTRACT, STRICT LIABILITY, OR TORT (INCLUDING NEGLIGENCE OR
// OTHERWISE) ARISING IN ANY WAY OUT OF THE USE OF THIS SOFTWARE, EVEN IF
// ADVISED OF THE POSSIBILITY OF SUCH DAMAGE.
// 
// --------------------------------------------------------------------------
// $Maintainer: Stephan Aiche $
// $Authors: Stephan Aiche $
// --------------------------------------------------------------------------

#ifndef OPENMS_ANALYSIS_QUANTITATION_TMTSIXPLEXQUANTITATIONMETHOD_H
#define OPENMS_ANALYSIS_QUANTITATION_TMTSIXPLEXQUANTITATIONMETHOD_H

#include <OpenMS/config.h>

#include <OpenMS/ANALYSIS/QUANTITATION/IsobaricQuantitationMethod.h>

namespace OpenMS
{
  /**
    @brief TMT 6plex quantitation to be used with the IsobaricQuantitation.
   
    @htmlinclude OpenMS_TMTSixPlexQuantitationMethod.parameters
  */
  class OPENMS_DLLAPI TMTSixPlexQuantitationMethod :
    public IsobaricQuantitationMethod
  {
public:
    /// Default c'tor
    TMTSixPlexQuantitationMethod();
    
    /// d'tor
    ~TMTSixPlexQuantitationMethod();

    /// Copy c'tor
    TMTSixPlexQuantitationMethod(const TMTSixPlexQuantitationMethod& other);

    /// Assignment operator
    TMTSixPlexQuantitationMethod & operator=(const TMTSixPlexQuantitationMethod& rhs);
    
    /// @brief Methods to implement from IsobaricQuantitationMethod
    /// @{
    
    const String& getName() const;
    
    const IsobaricChannelList& getChannelInformation() const;
    
    Size getNumberOfChannels() const;
    
    virtual Matrix<double> getIsotopeCorrectionMatrix() const;
    
    Size getReferenceChannel() const;
    
    /// @}
    
  private:
    /// the actuacl information on the different itraq4plex channels.
    IsobaricChannelList channels_;
    
    /// The name of the quantitation method.
    static const String name_;
    
    /// The reference channel for this experiment.
    Size reference_channel_;
    
  protected:
    /// implemented for DefaultParamHandler
    void setDefaultParams_();
    
    /// implemented for DefaultParamHandler
    void updateMembers_();

  };
} // namespace

#endif // OPENMS_ANALYSIS_QUANTITATION_TMTSIXPLEXQUANTITATIONMETHOD_H