/usr/lib/R/site-library/Biostrings/UnitTests/runit-pairwiseAlignment.R is in r-bioc-biostrings 2.32.1-1.
This file is owned by root:root, with mode 0o644.
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1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 129 130 131 132 133 134 135 136 137 138 139 140 141 142 143 144 145 146 147 148 149 150 151 152 153 154 155 156 157 158 159 160 161 162 163 164 165 166 167 168 169 170 171 172 173 174 175 176 177 178 179 180 181 182 183 184 185 186 187 188 189 190 | test_pairwiseAlignment_emptyString <- function()
{
string1 <- DNAStringSet("")
string2 <- DNAStringSet("ACGT")
## Empty pattern.
alignment <- pairwiseAlignment(string1, string2)
checkEquals(as.character(aligned(pattern(alignment))), "")
checkEquals(as.character(aligned(subject(alignment))), "")
checkEquals(score(alignment), -26)
checkEquals(pairwiseAlignment(string1, string2, scoreOnly = TRUE), -26)
## Empty subject.
alignment <- pairwiseAlignment(string2, string1)
checkEquals(as.character(aligned(pattern(alignment))), "")
checkEquals(as.character(aligned(subject(alignment))), "")
checkEquals(score(alignment), -26)
checkEquals(pairwiseAlignment(string2, string1, scoreOnly = TRUE), -26)
## Empty pattern and subject.
alignment <- pairwiseAlignment(string1, string1)
checkEquals(as.character(aligned(pattern(alignment))), "")
checkEquals(score(alignment), 0)
checkEquals(pairwiseAlignment(string1, string1, scoreOnly = TRUE), 0)
}
test_pairwiseAlignment_emptyLocalAlign <- function()
{
string1 <- DNAString("A")
string2 <- DNAString("T")
alignment <- pairwiseAlignment(string1, string2, type = "local")
checkEquals(as.character(aligned(pattern(alignment))), "")
checkEquals(as.character(aligned(subject(alignment))), "")
checkEquals(score(alignment), 0)
checkEquals(pairwiseAlignment(string1, string2, type = "local", scoreOnly = TRUE), 0)
}
test_pairwiseAlignment_gappedLocalAlign <- function()
{
string1 <- DNAString("TCAGTTGCCAAACCCGCT")
string2 <- DNAString("AGGGTTGACATCCGTTTT")
sigma <- nucleotideSubstitutionMatrix(match = 10, mismatch = -10, baseOnly = TRUE)
alignment <-
pairwiseAlignment(string1, string2, substitutionMatrix = sigma,
gapOpening = -12, gapExtension = -3, type="local")
checkEquals(as.character(aligned(pattern(alignment))), "GTTGCCAAACCCG")
checkEquals(as.character(aligned(subject(alignment))), "GTTGACAT--CCG")
checkEquals(score(alignment), 52)
}
test_pairwiseAlignment_backToBackIndel <- function()
{
mat <- nucleotideSubstitutionMatrix(match = 1, mismatch = -10, baseOnly = TRUE)
string1 <- DNAString("AC")
string2 <- DNAString("AT")
alignment <- pairwiseAlignment(string1, string2, gapOpening = 0, substitutionMatrix = mat)
alignmentScore <- pairwiseAlignment(string1, string2, gapOpening = 0, substitutionMatrix = mat, scoreOnly = TRUE)
checkEquals(as.character(aligned(pattern(alignment))), "A-")
checkEquals(as.character(aligned(subject(alignment))), "AT")
checkEquals(score(alignment), -7)
checkEquals(alignmentScore, -7)
}
test_pairwiseAlignment_editDistance <- function()
{
string1 <- DNAString("ACTTCACCAGCTCCCTGGCGGTAAGTTGATCAAAGGAAACGCAAAGTTTTCAAG")
string2 <- DNAString("GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
mat <- nucleotideSubstitutionMatrix(match = 0, mismatch = -1, baseOnly = TRUE)
globalAlign <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = 0, gapExtension = -1)
globalAlignScore <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = 0, gapExtension = -1, scoreOnly = TRUE)
checkEquals(as.character(pattern(globalAlign)), "ACTTCACCAGCTCCCTGGCGG-TAAGTTGATC-A-AAGGA-A-ACGCA-A-AGTTTTCAAG")
checkEquals(as.character(subject(globalAlign)), "GTTTCACTA-CTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
checkEquals(compareStrings(globalAlign), "??TTCAC?A+CT?CCT??CGG-TAAGT??AT?-A-AA??A-A-A???A-A-A?TTTTCA??")
checkEquals(score(globalAlign), -25)
checkEquals(globalAlignScore, -25)
}
test_pairwiseAlignment_zeroOpening <- function()
{
string1 <- DNAString("ACTTCACCAGCTCCCTGGCGGTAAGTTGATCAAAGGAAACGCAAAGTTTTCAAG")
string2 <- DNAString("GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
mat <- nucleotideSubstitutionMatrix(match = 1, mismatch = -3, baseOnly = TRUE)
globalAlign <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = 0, gapExtension = -5)
globalAlignScore <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = 0, gapExtension = -5, scoreOnly = TRUE)
overlapAlign <-
pairwiseAlignment(string1, string2, type = "overlap", substitutionMatrix = mat, gapOpening = 0, gapExtension = -5)
overlapAlignScore <-
pairwiseAlignment(string1, string2, type = "overlap", substitutionMatrix = mat, gapOpening = 0, gapExtension = -5,
scoreOnly = TRUE)
localAlign <-
pairwiseAlignment(string1, string2, type = "local", substitutionMatrix = mat, gapOpening = 0, gapExtension = -5)
localAlignScore <-
pairwiseAlignment(string1, string2, type = "local", substitutionMatrix = mat, gapOpening = 0, gapExtension = -5,
scoreOnly = TRUE)
checkEquals(as.character(pattern(globalAlign)), "ACTTCACCAGCTCCCTGGCGG-TAAGTTGATC-A-AAGGA-A-ACGCA-A-AGTTTTCAAG")
checkEquals(as.character(subject(globalAlign)), "GTTTCACTA-CTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
checkEquals(compareStrings(globalAlign), "??TTCAC?A+CT?CCT??CGG-TAAGT??AT?-A-AA??A-A-A???A-A-A?TTTTCA??")
checkEquals(score(globalAlign), -55)
checkEquals(globalAlignScore, -55)
checkEquals(as.character(pattern(overlapAlign)), "G")
checkEquals(as.character(subject(overlapAlign)), "G")
checkEquals(score(overlapAlign), 1)
checkEquals(overlapAlignScore, 1)
checkEquals(as.character(pattern(localAlign)), "GGTAAGT")
checkEquals(as.character(subject(localAlign)), "GGTAAGT")
checkEquals(score(localAlign), 7)
checkEquals(localAlignScore, 7)
}
test_pairwiseAlignment_fixedSubstitutionMatrix <- function()
{
string1 <- DNAString("ACTTCACCAGCTCCCTGGCGGTAAGTTGATCAAAGGAAACGCAAAGTTTTCAAG")
string2 <- DNAString("GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
mat <- nucleotideSubstitutionMatrix(match = 1, mismatch = -3, baseOnly = TRUE)
globalAlign <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = -5, gapExtension = -2)
globalAlignScore <-
pairwiseAlignment(string1, string2, substitutionMatrix = mat, gapOpening = -5, gapExtension = -2, scoreOnly = TRUE)
overlapAlign <-
pairwiseAlignment(string1, string2, type = "overlap", substitutionMatrix = mat, gapOpening = -5, gapExtension = -2)
overlapAlignScore <-
pairwiseAlignment(string1, string2, type = "overlap", substitutionMatrix = mat, gapOpening = -5, gapExtension = -2,
scoreOnly = TRUE)
localAlign <-
pairwiseAlignment(string1, string2, type = "local", substitutionMatrix = mat, gapOpening = -5, gapExtension = -2)
localAlignScore <-
pairwiseAlignment(string1, string2, type = "local", substitutionMatrix = mat, gapOpening = -5, gapExtension = -2,
scoreOnly = TRUE)
checkEquals(as.character(pattern(globalAlign)), "ACTTCACCAGCTCCCTGGCGGTAAGTTGATC---AAAGG---AAACGCAAAGTTTTCAAG")
checkEquals(as.character(subject(globalAlign)), "GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
checkEquals(compareStrings(globalAlign), "??TTCAC?A??TCC?T???GGTAAGT??AT?---AAA??---AAA???A?A?TTTTCA??")
checkEquals(score(globalAlign), -52)
checkEquals(globalAlignScore, -52)
checkEquals(as.character(pattern(overlapAlign)), "G")
checkEquals(as.character(subject(overlapAlign)), "G")
checkEquals(score(overlapAlign), 1)
checkEquals(overlapAlignScore, 1)
checkEquals(as.character(pattern(localAlign)), "GGTAAGT")
checkEquals(as.character(subject(localAlign)), "GGTAAGT")
checkEquals(score(localAlign), 7)
checkEquals(localAlignScore, 7)
}
test_pairwiseAlignment_qualityScoring <- function()
{
string1 <- DNAString("ACTTCACCAGCTCCCTGGCGGTAAGTTGATCAAAGGAAACGCAAAGTTTTCAAG")
string2 <- DNAString("GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
classes <- c("PhredQuality", "SolexaQuality", "IlluminaQuality")
for (qualityClass in classes) {
scoring <- qualitySubstitutionMatrices(qualityClass = qualityClass)["22", "22", c("1", "0")]
stringQuality <- do.call(qualityClass, list(22L))
globalAlign <-
pairwiseAlignment(string1, string2, patternQuality = stringQuality, subjectQuality = stringQuality)
globalAlignScore <-
pairwiseAlignment(string1, string2, scoreOnly = TRUE, patternQuality = stringQuality, subjectQuality = stringQuality)
overlapAlign <-
pairwiseAlignment(string1, string2, type = "overlap", patternQuality = stringQuality, subjectQuality = stringQuality)
overlapAlignScore <-
pairwiseAlignment(string1, string2, type = "overlap", scoreOnly = TRUE, patternQuality = stringQuality, subjectQuality = stringQuality)
localAlign <-
pairwiseAlignment(string1, string2, type = "local", patternQuality = stringQuality, subjectQuality = stringQuality)
localAlignScore <-
pairwiseAlignment(string1, string2, type = "local", scoreOnly = TRUE, patternQuality = stringQuality, subjectQuality = stringQuality)
checkEquals(as.character(pattern(globalAlign)), "ACTTCACCAGCTCCCTGGCGGTAAGTTGATC---AAAGG---AAACGCAAAGTTTTCAAG")
checkEquals(as.character(subject(globalAlign)), "GTTTCACTACTTCCTTTCGGGTAAGTAAATATATAAATATATAAAAATATAATTTTCATC")
checkEquals(compareStrings(globalAlign), "??TTCAC?A??TCC?T???GGTAAGT??AT?---AAA??---AAA???A?A?TTTTCA??")
checkEquals(score(globalAlign), sum(c(33, 21) * scoring) - 44, tolerance = 1e-6)
checkEquals(globalAlignScore, sum(c(33, 21) * scoring) - 44, tolerance = 1e-6)
checkEquals(as.character(pattern(overlapAlign)), "G")
checkEquals(as.character(subject(overlapAlign)), "G")
checkEquals(score(overlapAlign), scoring[[1]], tolerance = 1e-6)
checkEquals(overlapAlignScore, scoring[[1]], tolerance = 1e-6)
checkEquals(as.character(pattern(localAlign)), "GGTAAGT")
checkEquals(as.character(subject(localAlign)), "GGTAAGT")
checkEquals(score(localAlign), 7 * scoring[[1]], tolerance = 1e-6)
checkEquals(localAlignScore, 7 * scoring[[1]], tolerance = 1e-6)
}
TRUE
}
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