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<?xml version='1.0' encoding='UTF-8'?>
<!-- XML Authors: Corinne Maufrais, Nicolas Joly and Bertrand Neron,             -->
<!-- 'Biological Software and Databases' Group, Institut Pasteur, Paris.         -->
<!-- Distributed under LGPLv2 License. Please refer to the COPYING.LIB document. -->
<program>
  <head>
    <name>dca</name>
    <version>1.1</version>
    <doc>
      <title>DCA</title>
      <description>
        <text lang="en">Divide-and-Conquer Multiple Sequence Alignment</text>
      </description>
      <authors>J. Stoye</authors>
      <reference>A.W.M. Dress, G. Fullen, S.W. Perrey, A Divide and Conquer Approach to Multiple Alignment, Proceedings of the Third International Conference on Intelligent Systems for Molecular Biology (ISMB 95), AAAI Press, Menlo Park, CA, USA, 107-113, 1995.</reference>
      <reference>J. Stoye, Multiple Sequence Alignment with the Divide-and-Conquer Method, Gene 211(2), GC45-GC56, 1998. (Gene-COMBIS)</reference>
      <comment>
        <text lang="en">Divide-and-Conquer Multiple Sequence Alignment  (DCA) is a program for producing fast, high quality simultaneous multiple sequence alignments of amino acid, RNA, or DNA sequences. The program is based on the DCA algorithm, a heuristic approach to sum-of-pairs (SP) optimal alignment that has been developed at the FSPM  over the years 1995-97.</text>
      </comment>
      <homepagelink>http://bibiserv.techfak.uni-bielefeld.de/dca/</homepagelink>
      <sourcelink>http://bibiserv.techfak.uni-bielefeld.de/download/tools/dca.html</sourcelink>
    </doc>
    <category>alignment:multiple</category>
    <command>dca</command>
  </head>
  <parameters>
    <parameter ismandatory="1"  issimple="1">
      <name>seq</name>
      <prompt lang="en">Sequences File</prompt>
      <type>
        <datatype>
          <class>Sequence</class>
        </datatype>
        <dataFormat>FASTA</dataFormat>
      </type>
      <format>
        <code proglang="perl">" $value"</code>
        <code proglang="python">" "+str(value)</code>
      </format>
      <argpos>100</argpos>
    </parameter>
    <paragraph>
      <name>control</name>
      <prompt lang="en">Control parameters</prompt>
      <parameters>
        <parameter>
          <name>cost</name>
          <prompt lang="en">Cost matrix (-c)</prompt>
          <type>
            <datatype>
              <class>Choice</class>
            </datatype>
          </type>
          <vdef>
            <value>null</value>
          </vdef>
          <vlist>
            <velem undef="1">
              <value>null</value>
              <label>Default: depends on sequences</label>
            </velem>
            <velem>
              <value>blosum30</value>
              <label>BLOSUM30</label>
            </velem>
            <velem>
              <value>blosum45</value>
              <label>BLOSUM45</label>
            </velem>
            <velem>
              <value>blosum62</value>
              <label>BLOSUM62</label>
            </velem>
            <velem>
              <value>pam160</value>
              <label>PAM160</label>
            </velem>
            <velem>
              <value>pam250</value>
              <label>PAM250</label>
            </velem>
            <velem>
              <value>unitcost</value>
              <label>Unitcost</label>
            </velem>
            <velem>
              <value>dna</value>
              <label>DNA</label>
            </velem>
            <velem>
              <value>rna</value>
              <label>RNA</label>
            </velem>
            <velem>
              <value>dnarna</value>
              <label>DNA/RNA</label>
            </velem>
          </vlist>
          <format>
            <code proglang="perl">(defined $value and $value ne $vdef)? " -c $value" : "" </code>
            <code proglang="python">( ""  , " -c " + str(value) )[ value is not None and value != vdef]</code>
          </format>
          <argpos>1</argpos>
        </parameter>
        <parameter>
          <name>gaps</name>
          <prompt lang="en">Penalize end gaps as internal gaps (-g)</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="perl"> ($value)? " -g ":""</code>
            <code proglang="python">("" , " -g ")[ value ]</code>
          </format>
          <argpos>1</argpos>
          <comment>
            <text lang="en">Default: free shift</text>
          </comment>
        </parameter>
        <parameter>
          <name>approximate</name>
          <prompt lang="en">Use approximate cut positions (-a)</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="perl"> ($value)? " -a":""</code>
            <code proglang="python">("" , " -a")[ value ]</code>
          </format>
          <argpos>1</argpos>
          <comment>
            <text lang="en">On: FastDCA (use approximate cut positions); Off: slower, more accurate algorithm (search for exact cut positions)</text>
          </comment>
        </parameter>
        <parameter>
          <name>intensity</name>
          <prompt lang="en">Weight intensity (-b)</prompt>
          <type>
            <datatype>
              <class>Float</class>
            </datatype>
          </type>
          <vdef>
            <value>0.0</value>
          </vdef>
          <format>
            <code proglang="perl">(defined $value and $value != $vdef)? " -b $value" : "" </code>
            <code proglang="python">( ""  , " -b " + str(value) )[ value is not None and value != vdef]</code>
          </format>
          <ctrl>
            <message>
              <text lang="en">Weight intensity must be &gt;= 0.0 and &lt;= 1.0</text>
            </message>
            <code proglang="perl">$intensity &gt;= 0.0 and $intensity &lt;= 1.0</code>
            <code proglang="python">intensity &gt;= 0.0 and intensity &lt;= 1.0</code>
          </ctrl>
          <argpos>1</argpos>
        </parameter>
        <parameter>
          <name>recursion</name>
          <prompt lang="en">Recursion stop size (-l)</prompt>
          <type>
            <datatype>
              <class>Integer</class>
            </datatype>
          </type>
          <vdef>
            <value>30</value>
          </vdef>
          <format>
            <code proglang="perl"> (defined $value and $value != $vdef)? " -l $value" : "" </code>
            <code proglang="python">( ""  , " -l " + str(value) )[ value is not None and value != vdef]</code>
          </format>
          <argpos>1</argpos>
          <comment>
            <text lang="en">5 ... 100 recommended; small: faster algorithm, maybe worse.</text>
          </comment>
        </parameter>
        <parameter>
          <name>window</name>
          <prompt lang="en">Window size (-w)</prompt>
          <type>
            <datatype>
              <class>Integer</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="perl">(defined $value and  $value != $vdef)? " -w $value" : "" </code>
            <code proglang="python">( ""  , " -w " + str(value) )[ value is not None and value != vdef]</code>
          </format>
          <argpos>1</argpos>
          <comment>
            <text lang="en">To correct the alignment in the proximity of division sites, the sequences can be re-aligned inside a window of size w &gt;= 0 placed across each slicing site.</text>
          </comment>
        </parameter>
      </parameters>
    </paragraph>
    <paragraph>
      <name>output</name>
      <prompt lang="en">Output parameters</prompt>
      <parameters>
        <parameter ishidden="1">
          <name>quiet</name>
          <type>
            <datatype>
              <class>String</class>
            </datatype>
          </type>
          <format>
            <code proglang="perl">" -q"</code>
            <code proglang="python">" -q"</code>
          </format>
          <argpos>1</argpos>
        </parameter>
        <parameter>
          <name>output_format</name>
          <prompt lang="en">Output format (-f)</prompt>
          <type>
            <datatype>
              <class>Choice</class>
            </datatype>
          </type>
          <vdef>
            <value>2</value>
          </vdef>
          <vlist>
            <velem>
              <value>1</value>
              <label>aln (1)</label>
            </velem>
            <velem>
              <value>2</value>
              <label>fasta (2)</label>
            </velem>
            <velem>
              <value>3</value>
              <label>nex (3)</label>
            </velem>
            <velem>
              <value>4</value>
              <label>dca (4)</label>
            </velem>
          </vlist>
          <format>
            <code proglang="perl">(defined $value and $value ne $vdef)? " -f $value" : "" </code>
            <code proglang="python">( ""  , " -f " + str(value) )[ value is not None and value != vdef]</code>
          </format>
          <argpos>1</argpos>
        </parameter>
        <parameter ishidden="1">
          <name>suppress_output</name>
          <prompt lang="en">Suppress output about progress of the program (-o)</prompt>
          <type>
            <datatype>
              <class>String</class>
            </datatype>
          </type>
          <format>
            <code proglang="perl">" -o"</code>
            <code proglang="python">" -o"</code>
          </format>
          <argpos>1</argpos>
        </parameter>
      </parameters>
    </paragraph>
    <parameter isstdout="1">
      <name>fasta_outfile</name>
      <prompt>Alignment file</prompt>
      <type>
        <datatype>
          <class>Alignment</class>
        </datatype>
        <dataFormat>
          <test param="output_format" eq="2">FASTA</test>
          <test param="output_format" eq="3">NEXUS</test>
        </dataFormat>
      </type>
      <precond>
        <code proglang="perl">$output_format eq "2" or $output_format eq "3"</code>
        <code proglang="python">output_format == "2" or output_format == "3"</code>
      </precond>
      <filenames>
        <code proglang="perl">"dca.out"</code>
        <code proglang="python">"dca.out"</code>
      </filenames>
    </parameter>
    <parameter isstdout="1">
      <name>aln_outfile</name>
      <prompt>DCA alignment file</prompt>
      <type>
        <datatype>
          <class>Dcalignment</class>
          <superclass>AbstractText</superclass>
        </datatype>
        <dataFormat>
          <test param="output_format" eq="1">CLUSTAL</test>
          <test param="output_format" eq="4">DCA</test>
        </dataFormat>
      </type>
      <precond>
        <code proglang="perl">$output_format eq "1" or $output_format eq "4"</code>
        <code proglang="python">output_format == "1" or output_format == "4"</code>
      </precond>
      <filenames>
        <code proglang="perl">"dca.out"</code>
        <code proglang="python">"dca.out"</code>
      </filenames>
    </parameter>
  </parameters>
</program>