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/usr/include/pbseq/alignment/tuples/CompressedDNATuple.hpp is in libblasr-dev 0~20161219-1.

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#ifndef _BLASR_COMPRESSED_DNA_TUPLE_HPP_
#define _BLASR_COMPRESSED_DNA_TUPLE_HPP_

#include "DNATuple.hpp"
#include "../../pbdata/CompressedSequence.hpp"

template<typename T_Sequence>
class CompressedDNATuple : public DNATuple {
    static const unsigned char mask = 0xf;
    public:
    CompressedDNATuple(const CompressedDNATuple & rhs)
    : DNATuple(rhs) { }

    int FromStringLR(Nucleotide *strPtr, TupleMetrics &tm) {
        //
        // Make sure the sequence contains all valid characters.
        //

        if (!CompressedSequence<T_Sequence>::Only4BitACTG(strPtr, tm.tupleSize)) 
            return 0;

        if (tm.tupleSize == 0)
            return 1;

        tuple = 0;
        Nucleotide *p;
        Nucleotide *endPtr = &strPtr[tm.tupleSize - 1];
        for (p = strPtr; p != endPtr; p++) {
            tuple += TwoBit[*p & mask];
            tuple <<=2;
        }
        //
        // The tuple size is guaranteed to be at least 
        // 1, so it's safe to add the last value.
        // This cannot be in the previous loop since
        // the shift shouldn't happen.
        tuple += TwoBit[*p & mask];
        return 1;
    }


    int FromStringRL(Nucleotide *strPtr, TupleMetrics &tm) {

        if (!CompressedSequence<T_Sequence>::Only4BitACTG((CompressedNucleotide*)strPtr, tm.tupleSize))
            return 0;

        if (tm.tupleSize == 0)
            return 1;

        tuple = 0;
        Nucleotide *p;
        for (p = strPtr + tm.tupleSize - 1; p > strPtr; p--) {
            tuple += TwoBit[*p & mask];
            tuple <<=2;
        }
        //
        // The tuple size is guaranteed to be at least 
        // 1, so it's safe to add the last value.
        // This cannot be in the previous loop since
        // the shift shouldn't happen.
        tuple += TwoBit[*p & mask];
        return 1;
    }
};

#endif // _BLASR_COMPRESSED_DNA_TUPLE_HPP_