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autodock_parameter_version 4.1       # used by autodock to validate parameter set
outlev -2                            # outlev min
parameter_file AD4.1_bound.dat       # New parameter library
#include_1_4_interactions 1.0        # test
intelec                              # calculate internal electrostatic energy

seed 28641 1106107140                # seeds for random generator

ligand_types C HD OA P               # ligand atom type names
fld 1pgp_rec.maps.fld                # grid_data_file
map 1pgp_rec.C.map                   # atom-specific affinity map
map 1pgp_rec.HD.map                  # atom-specific affinity map
map 1pgp_rec.OA.map                  # atom-specific affinity map
map 1pgp_rec.P.map                   # atom-specific affinity map
elecmap 1pgp_rec.e.map               # electrostatics map
desolvmap 1pgp_rec.d.map             # desolvation map

move 1pgp_lig.pdbqt                  # small molecule
about 22.894 28.598 40.259           # small molecule center
tran0 22.894 28.598 40.259           # small molecule center

rmstol 2.0                           # cluster_tolerance/A


ga_pop_size 15                      # number of individuals in population
ga_num_evals 20                     # maximum number of energy evaluations
ga_num_generations 2                 # maximum number of generations
ga_elitism 1                         # number of top individuals to survive to next generation
set_ga                               # set the above parameters for GA or LGA

sw_max_its 3                        # iterations of Solis & Wets local search
ls_search_freq 0.01                  # probability of performing local search on individual
set_psw1                             # set the above pseudo-Solis & Wets parameters

accs 10
rejs  5
cycles 10
simanneal 500
ga_run 1000                             # do this many hybrid GA-LS runs
do_local_only  500                             # do this many hybrid GA-LS runs
do_local_only   10