/usr/include/ncbi/lookup.h is in libncbi6-dev 6.1.20110713-3ubuntu2.
This file is owned by root:root, with mode 0o644.
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* ===========================================================================
*
* PUBLIC DOMAIN NOTICE
* National Center for Biotechnology Information
*
* This software/database is a "United States Government Work" under the
* terms of the United States Copyright Act. It was written as part of
* the author's official duties as a United States Government employee and
* thus cannot be copyrighted. This software/database is freely available
* to the public for use. The National Library of Medicine and the U.S.
* Government have not placed any restriction on its use or reproduction.
*
* Although all reasonable efforts have been taken to ensure the accuracy
* and reliability of the software and data, the NLM and the U.S.
* Government do not and cannot warrant the performance or results that
* may be obtained by using this software or data. The NLM and the U.S.
* Government disclaim all warranties, express or implied, including
* warranties of performance, merchantability or fitness for any particular
* purpose.
*
* Please cite the author in any work or product based on this material.
*
* ===========================================================================
*/
/*****************************************************************************
File name: lookup.h
Author: Tom Madden
Contents: defines and prototype used by lookup.c.
******************************************************************************/
/* File Name: lookup.h
*
* Author: Tom Madden
*
* Version Creation Date: 10/26/95
*
* $Revision: 6.36 $
*
* File Description:
* Functions that format traditional BLAST output.
*
* Modifications:
* --------------------------------------------------------------------------
* Date Name Description of modification
* ------- ---------- -----------------------------------------------------
*
* ==========================================================================
*
*
* RCS Modification History:
* $Log: lookup.h,v $
* Revision 6.36 2007/03/14 16:39:29 papadopo
* force PV array to use 32-bit data types only, for compatibility with the new blast engine
*
* Revision 6.35 2005/07/28 14:57:10 coulouri
* remove dead code
*
* Revision 6.34 2004/02/04 21:54:53 dondosha
* Macro correction for 12/18 discontiguous template
*
* Revision 6.33 2003/01/10 17:48:01 dondosha
* Corrections in 2 macros
*
* Revision 6.32 2002/08/30 15:48:17 dondosha
* MegaBlastWordFinderDeallocate prototype moved from mblast.h
*
* Revision 6.31 2002/05/20 21:28:29 dondosha
* Tiny correction in macro definitions for the optimal 11/18 discontiguous word template
*
* Revision 6.30 2002/05/17 21:39:16 dondosha
* 1. Added 2 optimal discontiguoutemplates for length 21;
* 2. Changed the optimal template for length 18
*
* Revision 6.29 2002/05/14 22:20:20 dondosha
* Renamed maximal discontiguous template type into optimal
*
* Revision 6.28 2002/04/09 18:19:47 dondosha
* Changed #ifdefs to conditionals, allowing different discontiguous templates in a single binary
*
* Revision 6.27 2002/04/04 21:18:50 dondosha
* Added more macros to be used by discontiguous megablast
*
* Revision 6.26 2002/04/01 22:29:24 dondosha
* Added pair of parentheses in macro definition
*
* Revision 6.25 2002/03/26 21:15:55 dondosha
* Added macro definitions to allow template length 21
*
* Revision 6.24 2002/02/15 23:35:01 dondosha
* Allow hash table and two templates for megablast
*
* Revision 6.23 2001/12/28 20:46:21 dondosha
* 1. Mega BLAST related parameters moved into a separate structure
* 2. Environment variables for discontiguous words, etc. changed to options
* 3. Extension from discontiguous word with length 18 implemented
*
* Revision 6.22 2001/12/04 17:13:08 dondosha
* Made number of stacks for megablast word processing depend on query and database
*
* Revision 6.21 2001/11/13 18:22:13 dondosha
* Added another discontiguous model definition for Mega BLAST
*
* Revision 6.20 2001/10/12 21:32:46 dondosha
* Added discontiguous word capability to megablast
*
* Revision 6.19 2001/07/20 18:57:07 dondosha
* Added and changed some megablast related defines
*
* Revision 6.18 2000/07/10 17:17:37 dondosha
* Use several stacks in MegaBlast to speed up search for small word sizes
*
* Revision 6.17 2000/07/07 21:20:08 vakatov
* Get all "#include" out of the 'extern "C" { }' scope!
*
* Revision 6.16 2000/05/31 14:04:50 dondosha
* Added member stack_size to MbStack structure
*
* Revision 6.15 2000/03/03 18:00:11 dondosha
* Added prototype for MegaBlastLookupTableDup, plus cosmetic changes
*
* Revision 6.14 2000/02/17 19:00:45 shavirin
* Removed theCacheSize parameter from everywhere.
*
* Revision 6.13 2000/02/11 20:52:25 dondosha
* Added Webb Miller s lookup table and related prototypes
*
* Revision 6.12 2000/02/01 21:05:56 dondosha
* Added prototype for mb_lookup_position_aux_destruct - modification for megablast
*
* Revision 6.11 2000/01/11 17:27:02 shavirin
* Added elements theTable and theCacheSize into LookupTable
* Added parameters theCacheSize into lookup_new and BLAST_WordFinderNew
*
* Revision 6.9 1999/12/21 21:33:24 shavirin
* Added parameter mod_lookup_table_memory to the lookup structure.
*
* Revision 6.8 1999/09/29 17:20:12 madden
* Deallocate ModLookupPositionPtr memory
*
* Revision 6.7 1999/09/28 20:14:34 madden
* Joerg changes to mimize cache misses
*
* Revision 6.6 1999/09/16 16:56:39 madden
* Changes to lookup_new for long words
*
* Revision 6.5 1999/09/16 14:16:27 madden
* lookup_find_init returns Uint1Ptr instead of CharPtr
*
* Revision 6.4 1998/09/22 16:27:48 madden
* Added function lookup_position_aux_destruct
*
* Revision 6.3 1998/07/27 18:14:18 madden
* lookup_get_memory replaces call to MemNew
*
* Revision 6.2 1998/04/15 20:25:58 madden
* Auxillary structure added to speed-up saving words for queries
*
* Revision 6.1 1998/02/26 22:34:40 madden
* Changes for 16 bit windows
*
* Revision 6.0 1997/08/25 18:53:25 madden
* Revision changed to 6.0
*
* Revision 1.4 1996/09/25 14:17:30 madden
* removed discontiguous options.
*
* Revision 1.3 1996/09/12 21:12:59 madden
* Added new function to save an already computed index, lookup_add_index.
*
* Revision 1.2 1996/08/15 18:57:10 madden
* Changed context from Int1 to Int2.
*
* Revision 1.1 1996/08/05 19:48:50 madden
* Initial revision
*
* Revision 1.10 1996/07/18 22:00:02 madden
* Changes for multiple contexts.
*
* Revision 1.9 1996/06/20 17:00:11 madden
* Added "__cplusplus" define.
*
* Revision 1.8 1996/06/20 16:15:57 madden
* Replaced int's with Int4's.
*
* Revision 1.7 1996/05/22 20:22:43 madden
* removed unused prototypes.
*
* Revision 1.6 1996/05/16 19:50:15 madden
* Added documentation block.
*
* Revision 1.5 1996/05/03 19:55:24 madden
* Removed FnPtr for lookup_find.
*
* Revision 1.4 1996/04/04 20:47:55 madden
* Made lookup_find into two functions, that are statics.
*
* Revision 1.3 1996/02/28 21:38:36 madden
* Changed prototypes for discontiguous words.
*
* Revision 1.2 1995/12/26 20:28:54 madden
* *** empty log message ***
*
* Revision 1.1 1995/12/08 15:48:23 madden
* Initial revision
*
*/
#ifndef _LOOKUP_
#define _LOOKUP_
#include <ncbi.h>
#ifdef __cplusplus
extern "C" {
#endif
/*
Structure that keeps a block of memory for the functions in lookup.c
Most often used instead of a MemNew call in AddPositionToLookupTable.
*/
typedef struct lookup_memory {
Uint1Ptr current, /* Current position of pointer to memory. */
start; /* Start of memory (for deallocation). */
size_t remaining; /* How much memory remains in allocated block. */
struct lookup_memory *next;
} LookupMemory, PNTR LookupMemoryPtr;
typedef struct orig_lookup_position {
Int4 position; /* position along the query */
Int1 context; /* "context" of hit, for use by BLASTContextStructPtr.*/
struct orig_lookup_position *next; /* other positions */
} OrigLookupPosition, PNTR OrigLookupPositionPtr;
/* some defines for the pv_array, as this changes from 32-bit to 64-bit systems. */
#if 0 /* 64-bit versions turned off for new engine compatibility */
#define PV_ARRAY_TYPE Uint8 /* The pv_array 'native' type. */
#define PV_ARRAY_BYTES 8 /* number of BYTES in 'native' type. */
#define PV_ARRAY_BTS 6 /* bits-to-shift from lookup_index to pv_array index. */
#define PV_ARRAY_MASK 63 /* amount to mask off. */
#else
#define PV_ARRAY_TYPE Uint4 /* The pv_array 'native' type. */
#define PV_ARRAY_BYTES 4 /* number of BYTES in 'native' type. */
#define PV_ARRAY_BTS 5 /* bits-to-shift from lookup_index to pv_array index. */
#define PV_ARRAY_MASK 31 /* amount to mask off. */
#endif
#define PV_ARRAY_FACTOR 0.5 /* The fraction of sites that must have at least one hit to not use PV_ARRAY. */
/* Largest query length for which diagonal array is to be used in megablast */
#define MAX_DIAG_ARRAY 100000
#define NUC_MASK 0xfc
#define PACK_EXTRA_CODE(ecode,val,mask) {ecode = ((ecode<<2) & mask) | val;}
#define GET_NEXT_PACKED_NUCL(s,n,val) { n = (n-1)&0x03; s = s + (n&(n>>1)&0x01); val = ((*s)>>(n<<1)) & 0x00000003; }
/* OPTIMAL templates */
/* 1,110,110,110,110,111 - 12 of 16 */
/* 1,110,010,110,110,111 - 11 of 16 */
#define MASK1_OPT 0x0000003f
#define MASK2_OPT 0x00000f00
#define MASK3_OPT 0x0003c000
#define MASK4_12_OPT 0x00f00000
#define MASK4_11_OPT 0x00300000
#define MASK5_OPT 0xfc000000
/* 12 of 16 */
#define GET_WORD_INDEX_12_16_OPT(n) (((n)&MASK1_OPT) | (((n)&MASK2_OPT)>>2) | (((n)&MASK3_OPT)>>4) | (((n)&MASK4_12_OPT)>>6) | (((n)&MASK5_OPT)>>8))
/* 11 of 16 */
#define GET_WORD_INDEX_11_16_OPT(n) (((n)&MASK1_OPT) | (((n)&MASK2_OPT)>>2) | (((n)&MASK3_OPT)>>4) | (((n)&MASK4_11_OPT)>>6) | (((n)&MASK5_OPT)>>10))
/* 111,010,110,010,110,111 - 12 of 18 */
/* 111,010,010,110,010,111 - 11 of 18 */
#define MASK1_18_OPT 0x00000003
#define MASK2_12_18_OPT 0x000000f0
#define MASK2_11_18_OPT 0x00000030
#define MASK3_11_18_OPT 0x00003c00
#define MASK3_12_18_OPT 0x00000c00
#define MASK4_11_18_OPT 0x00030000
#define MASK4_12_18_OPT 0x000f0000
#define MASK5_18_OPT 0x00c00000
#define MASK6_18_OPT 0xfc000000
/* 12 of 18 */
#define GET_WORD_INDEX_12_18_OPT(n) ((((n)&MASK1_18_OPT)<<4) | (((n)&MASK2_12_18_OPT)<<2) | ((n)&MASK3_12_18_OPT) | (((n)&MASK4_12_18_OPT)>>4) | (((n)&MASK5_18_OPT)>>6) | (((n)&MASK6_18_OPT)>>8))
/* 11 of 18 */
#define GET_WORD_INDEX_11_18_OPT(n) ((((n)&MASK1_18_OPT)<<4) | (((n)&MASK2_11_18_OPT)<<2) | (((n)&MASK3_11_18_OPT)>>2) | (((n)&MASK4_11_18_OPT)>>4) | (((n)&MASK5_18_OPT)>>8) | (((n)&MASK6_18_OPT)>>10))
#define MASK_EXTRA_OPT 0x0000000f
#define GET_EXTRA_CODE_18_OPT(s) (((*(s+1))<<2) | (*(s+2))) & MASK_EXTRA_OPT
#define GET_EXTRA_CODE_PACKED_4_18_OPT(s) ((*(s+1))>>4)
#define GET_EXTRA_CODE_PACKED_18_OPT(s,b,val,ecode) {GET_NEXT_PACKED_NUCL(s,b,ecode); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode, val,MASK_EXTRA_OPT);}
#define GET_AMBIG_CONDITION_18_OPT(s) (((*(s+1))&NUC_MASK) | ((*(s+2))&NUC_MASK))
/* 111,010,010,110,010,010,111 - 12 of 21 */
/* 111,010,010,100,010,010,111 - 11 of 21 */
#define MASK1_21_OPT 0x00000030
#define MASK2_12_21_OPT 0x00003c00
#define MASK2_11_21_OPT 0x00003000
#define MASK3_21_OPT 0x00030000
#define MASK4_21_OPT 0x00c00000
#define MASK5_21_OPT 0xfc000000
#define GET_WORD_INDEX_12_21_OPT(n) ((((n)&MASK1_21_OPT)<<4) | ((n)&MASK2_12_21_OPT) | (((n)&MASK3_21_OPT)>>2) | (((n)&MASK4_21_OPT)>>6) | (((n)&MASK5_21_OPT)>>8))
#define GET_WORD_INDEX_11_21_OPT(n) ((((n)&MASK1_21_OPT)<<4) | (((n)&MASK2_11_21_OPT)>>2) | (((n)&MASK3_21_OPT)>>4) | (((n)&MASK4_21_OPT)>>8) | (((n)&MASK5_21_OPT)>>10))
#define MASK_EXTRA_21_OPT 0x000000ff
#define GET_EXTRA_CODE_21_OPT(s) ((((*(s+1))<<6) | ((*(s+3))<<4) | ((*(s+4))<<2) | (*(s+5))) & MASK_EXTRA_21_OPT)
#define GET_AMBIG_CONDITION_21_OPT(s) (((*(s+1))&NUC_MASK) | ((*(s+3))&NUC_MASK) | ((*(s+4))&NUC_MASK) | ((*(s+5))&NUC_MASK))
#define GET_EXTRA_CODE_PACKED_4_21_OPT(s) ((((*(s+1))&0x0f)<<2)|((*(s+1))&0xc0)|((*(s+2))>>6))
#define GET_EXTRA_CODE_PACKED_21_OPT(s,b,val,ecode) {GET_NEXT_PACKED_NUCL(s,b,ecode); GET_NEXT_PACKED_NUCL(s,b,val); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode,val,MASK_EXTRA_21_OPT); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode,val,MASK_EXTRA_21_OPT); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode,val,MASK_EXTRA_21_OPT);}
/* CODING TEMPLATES */
/* 111,110,110,110,110,1 - 12 of 16 */
/* 110,110,110,110,110,1 - 11 of 16 */
#define MASK1 0x00000003
#define MASK2 0x000000f0
#define MASK3 0x00003c00
#define MASK4 0x000f0000
#define MASK5_12 0xffc00000
#define MASK5_11 0x03c00000
#define MASK6 0xf0000000
/* 12 of 16 */
#define GET_WORD_INDEX_12_16(n) (((n)&MASK1) | (((n)&MASK2)>>2) | (((n)&MASK3)>>4) | (((n)&MASK4)>>6) | (((n)&MASK5_12)>>8))
/* 11 of 16 */
#define GET_WORD_INDEX_11_16(n) (((n)&MASK1) | (((n)&MASK2)>>2) | (((n)&MASK3)>>4) | (((n)&MASK4)>>6) | (((n)&MASK5_11)>>8) | (((n)&MASK6)>>10))
/* 10,110,110,110,110,110,1 - 12 of 18 */
/* 10,110,110,010,110,110,1 - 11 of 18 */
#define MASK1_18 0x0000000f
#define MASK2_18 0x000003c0
#define MASK3_11_18 0x00003000
#define MASK3_12_18 0x0000f000
#define MASK4_18 0x003c0000
#define MASK5_18 0x0f000000
#define MASK6_18 0xc0000000
/* 12 of 18 */
#define GET_WORD_INDEX_12_18(n) ((((n)&MASK1_18)<<2) | ((n)&MASK2_18) | (((n)&MASK3_12_18)>>2) | (((n)&MASK4_18)>>4) | (((n)&MASK5_18)>>6) | (((n)&MASK6_18)>>8))
/* 11 of 18 */
#define GET_WORD_INDEX_11_18(n) ((((n)&MASK1_18)<<2) | ((n)&MASK2_18) | (((n)&MASK3_11_18)>>2) | (((n)&MASK4_18)>>6) | (((n)&MASK5_18)>>8) | (((n)&MASK6_18)>>10))
#define MASK_EXTRA_18 0x00000003
#define GET_EXTRA_CODE_18(s) ((*(s+2)) & MASK_EXTRA_18)
#define GET_EXTRA_CODE_PACKED_4_18(s) (((*(s+1))>>4) & MASK_EXTRA_18)
#define GET_EXTRA_CODE_PACKED_18(s,b,val,ecode) {GET_NEXT_PACKED_NUCL(s,b,val); GET_NEXT_PACKED_NUCL(s,b,ecode);}
#define GET_AMBIG_CONDITION_18(s) ((*(s+2))&NUC_MASK)
/* 10,010,110,110,110,010,110,1 - 12 of 21 */
/* 10,010,110,010,110,010,110,1 - 11 of 21 */
#define MASK1_21 0x00000003
#define MASK2_21 0x000003c0
#define MASK3_12_21 0x0000f000
#define MASK3_11_21 0x00003000
#define MASK4_21 0x003c0000
#define MASK5_21 0x03000000
#define MASK6_21 0xc0000000
#define GET_WORD_INDEX_12_21(n) ((((n)&MASK1_21)<<6) | (((n)&MASK2_21)<<2) | ((n)&MASK3_12_21) | (((n)&MASK4_21)>>2) | (((n)&MASK5_21)>>4) | (((n)&MASK6_21)>>8))
#define GET_WORD_INDEX_11_21(n) ((((n)&MASK1_21)<<6) | (((n)&MASK2_21)<<2) | ((n)&MASK3_11_21) | (((n)&MASK4_21)>>4) | (((n)&MASK5_21)>>6) | (((n)&MASK6_21)>>10))
#define MASK_EXTRA_21 0x0000003f
#define GET_EXTRA_CODE_21(s) ((((*(s+2))<<4) | ((*(s+3))<<2) | (*(s+5))) & MASK_EXTRA_21)
#define GET_AMBIG_CONDITION_21(s) (((*(s+2))&NUC_MASK) | ((*(s+3))&NUC_MASK) | ((*(s+5))&NUC_MASK))
#define GET_EXTRA_CODE_PACKED_4_21(s) (((*(s+1))&0x3c)|((*(s+2))>>6))
#define GET_EXTRA_CODE_PACKED_21(s,b,val,ecode) {GET_NEXT_PACKED_NUCL(s,b,val); GET_NEXT_PACKED_NUCL(s,b,ecode); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode,val,MASK_EXTRA_21); GET_NEXT_PACKED_NUCL(s,b,val); GET_NEXT_PACKED_NUCL(s,b,val); PACK_EXTRA_CODE(ecode,val,MASK_EXTRA_21);}
/* Define LookupPosition (ie a hit_info) such that it can be loaded into a register */
typedef Uint4 ModLookupPosition;
typedef Uint4 *ModLookupPositionPtr;
#define hinfo_get_pos(h) ((h)&0xffffff)
#define hinfo_get_context(h) (((h)>>24)&0xff)
#define hinfo_set(ptr_hinfo,p,c) ( *(ptr_hinfo) = (( ((Uint4)(c)) << 24) | ((Uint4)(p))) )
#if 1 /* To be deleted */
typedef struct mod_lt_entry {
Int4 num_used; /* num valid positions */
ModLookupPosition entries[3]; /* first postion */
} ModLAEntry, PNTR ModLAEntryPtr;
#endif
typedef struct megablast_stack {
Int4 diag, level, length;
} MbStack, PNTR MbStackPtr;
typedef struct megablast_lookup_table {
Int2 width; /* Number of bytes in hash value */
Int4 hashsize; /* = 2^(8*width) - 1 */
Int2 lpm; /* Minimal length of perfect match */
Int2 max_positions; /* Maximal number of positions for one hash value */
Int4Ptr hashtable; /* Array of positions */
Int4Ptr hashtable2; /* Array of positions for second template */
Int4Ptr next_pos; /* Extra positions stored here */
Int4Ptr next_pos2; /* Extra positions for the second template */
Uint4 mask;
Int4Ptr stack_index; /* Current number of elements in each stack */
Int4Ptr stack_size; /* Available memory for each stack */
MbStackPtr PNTR estack; /* Array of stacks for most recent hits */
Int4 num_stacks;
} MbLookupTable, PNTR MbLookupTablePtr;
typedef struct lookup_table {
Int4 char_size, /* number of bits per residue/bp */
wordsize, /* size of "word" */
reduced_wordsize, /* size of word */
array_size, /* size of table's array. */
mask; /* Used to mask off top set of bits. */
OrigLookupPositionPtr PNTR position; /* positions of the hits. */
OrigLookupPositionPtr PNTR position_aux; /* auxillary structure for keeping track of the last saved hit, to speed up saving of hits on very long sequences. */
LookupMemoryPtr mem_struct, /* contains memory. */
mem_struct_start; /* Start of LookupMemoryPtr chain. */
size_t memory_chunk; /* chunk size of memory. */
PV_ARRAY_TYPE *pv_array; /* presence vector, used for quick presence check */
Int4 num_pos_added;
Int4 num_unique_pos_added;
#if 1 /* To be deleted */
ModLAEntry *mod_lt; /* The new&improved lookup table */
#endif
Uint4Ptr theTable; /* Lookup table with variable length */
ModLookupPositionPtr mod_lookup_table_memory; /* Memory for new and improved lookup table. */
Int4 mod_lookup_table_size;/* Size for new and improved lookup table */
MbLookupTablePtr mb_lt; /* MegaBlast version of the lookup table */
} LookupTable, PNTR LookupTablePtr;
/*********************************************************************
Structure for the BLAST_WordFinder, used to find the initial
word-hits.
*********************************************************************/
typedef struct _blast_wordfinder {
Int4 wordsize;
Int2 compression_ratio;
LookupTablePtr lookup;
} BLAST_WordFinder, PNTR BLAST_WordFinderPtr;
LookupTablePtr LIBCALL lookup_new PROTO((Int2 alphabet_size, Int2 wordsize, Int2 reduced_wordsize));
LookupTablePtr LIBCALL lookup_destruct PROTO((LookupTablePtr lookup));
void LIBCALL lookup_add PROTO((LookupTablePtr lookup, CharPtr string, Int4 position, Int1 context));
void LIBCALL lookup_add_index PROTO((LookupTablePtr lookup, Int4 lookup_index, Int4 position, Int1 context));
Uint1Ptr LIBCALL lookup_find_init PROTO((LookupTablePtr lookup, Int4 PNTR lookup_index, Uint1Ptr string));
Boolean lookup_position_aux_destruct PROTO((LookupTablePtr lookup));
Boolean mb_lookup_position_aux_destruct PROTO((LookupTablePtr lookup));
LookupTablePtr MegaBlastLookupTableDup PROTO((LookupTablePtr lookup));
LookupTablePtr MegaBlastLookupTableDestruct PROTO((LookupTablePtr lookup));
BLAST_WordFinderPtr BLAST_WordFinderDestruct PROTO((BLAST_WordFinderPtr wfp));
BLAST_WordFinderPtr BLAST_WordFinderNew PROTO((Int2 alphabet_size, Int2 wordsize, Int2 compression_ratio, Boolean round_down));
BLAST_WordFinderPtr
MegaBlastWordFinderDeallocate PROTO((BLAST_WordFinderPtr wfp));
#ifdef __cplusplus
}
#endif
#endif /* _LOOKUP_ */
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