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<?xml version="1.0" encoding="ISO-8859-1"?>

<!-- XML Authors: Corinne Maufrais and Nicolas Joly,                             -->
<!-- 'Biological Software and Databases' Group, Institut Pasteur, Paris.         -->
<!-- Distributed under LGPLv2 License. Please refer to the COPYING.LIB document. -->

<program>
  <head>
    <name>edialign</name>
    <package>
      <name>EMBOSS</name>
      <version>6.3.1</version>
      <doc>
        <title>EMBOSS</title>
        <description>
          <text lang="en">European Molecular Biology Open Software Suite</text>
        </description>
        <authors>Rice,P. Longden,I. and Bleasby, A.</authors>
        <reference>EMBOSS: The European Molecular Biology Open Software Suite (2000)  Rice,P. Longden,I. and Bleasby, A. Trends in Genetics 16, (6) pp276--277</reference>
        <sourcelink>http://emboss.sourceforge.net/download</sourcelink>
        <homepagelink>http://emboss.sourceforge.net</homepagelink>
      </doc>
    </package>
    <doc>
      <title>edialign</title>
      <description>
        <text lang="en">Local multiple alignment of sequences</text>
      </description>
      <doclink>http://bioweb2.pasteur.fr/docs/EMBOSS/edialign.html</doclink>
      <doclink>http://emboss.sourceforge.net/docs/themes</doclink>
    </doc>
    <category>alignment:multiple</category>
    <command>edialign</command>
  </head>

  <parameters>

    <paragraph>
      <name>e_input</name>
      <prompt lang="en">Input section</prompt>

      <parameters>

        <parameter issimple="1" ismandatory="1">
          <name>e_sequences</name>
          <prompt lang="en">sequences option</prompt>
          <type>
            <datatype>
              <class>Sequence</class>
            </datatype>
            <dataFormat>EMBL</dataFormat>
            <dataFormat>FASTA</dataFormat>
            <dataFormat>GCG</dataFormat>
            <dataFormat>GENBANK</dataFormat>
            <dataFormat>NBRF</dataFormat>
            <dataFormat>CODATA</dataFormat>
            <dataFormat>RAW</dataFormat>
            <dataFormat>SWISSPROT</dataFormat>
            <dataFormat>GFF</dataFormat>
            <card>2,n</card>
          </type>
          <format>
            <code proglang="python">("", " -sequences=" + str(value))[value is not None]</code>
          </format>
          <argpos>1</argpos>
        </parameter>
      </parameters>
    </paragraph>

    <paragraph>
      <name>e_additional</name>
      <prompt lang="en">Additional section</prompt>

      <parameters>

        <parameter>
          <name>e_nucmode</name>
          <prompt lang="en">Nucleic acid sequence alignment mode</prompt>
          <type>
            <datatype>
              <class>Choice</class>
            </datatype>
          </type>
          <vdef>
            <value>n</value>
          </vdef>
          <vlist>
            <velem>
              <value>n</value>
              <label>Simple</label>
            </velem>
            <velem>
              <value>nt</value>
              <label>Translation</label>
            </velem>
            <velem>
              <value>ma</value>
              <label>Mixed alignments</label>
            </velem>
          </vlist>
          <format>
            <code proglang="python">("", " -nucmode=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <argpos>2</argpos>
          <comment>
            <text lang="en">Nucleic acid sequence alignment mode (simple, translated or mixed)</text>
          </comment>
        </parameter>

        <parameter>
          <name>e_revcomp</name>
          <prompt lang="en">Also consider the reverse complement</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -revcomp")[ bool(value) ]</code>
          </format>
          <argpos>3</argpos>
        </parameter>

        <parameter>
          <name>e_overlapw</name>
          <prompt lang="en">Use overlap weights</prompt>
          <type>
            <datatype>
              <class>Choice</class>
            </datatype>
          </type>
          <vdef>
            <value>1</value>
          </vdef>
          <vlist>
            <velem>
              <value>1</value>
              <label>Default (when nseq =&lt; 35)</label>
            </velem>
            <velem>
              <value>2</value>
              <label>Yes</label>
            </velem>
            <velem>
              <value>3</value>
              <label>No</label>
            </velem>
          </vlist>
          <format>
            <code proglang="python">("", " -overlapw=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <argpos>4</argpos>
          <comment>
            <text lang="en">By default overlap weights are used when Nseq =&lt;35 but you can set this to 'yes' or 'no'</text>
          </comment>
        </parameter>

        <parameter>
          <name>e_linkage</name>
          <prompt lang="en">Clustering method to construct sequence tree</prompt>
          <type>
            <datatype>
              <class>Choice</class>
            </datatype>
          </type>
          <vdef>
            <value>UPGMA</value>
          </vdef>
          <vlist>
            <velem>
              <value>UPGMA</value>
              <label>Upgma</label>
            </velem>
            <velem>
              <value>max</value>
              <label>Maximum linkage</label>
            </velem>
            <velem>
              <value>min</value>
              <label>Minimum linkage</label>
            </velem>
          </vlist>
          <format>
            <code proglang="python">("", " -linkage=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <argpos>5</argpos>
          <comment>
            <text lang="en">Clustering method to construct sequence tree (UPGMA, minimum linkage or maximum linkage)</text>
          </comment>
        </parameter>

        <parameter>
          <name>e_maxfragl</name>
          <prompt lang="en">Maximum fragment length (value greater than or equal to 0)</prompt>
          <type>
            <datatype>
              <class>Integer</class>
            </datatype>
          </type>
          <vdef>
            <value>40</value>
          </vdef>
          <format>
            <code proglang="python">("", " -maxfragl=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <ctrl>
            <message>
              <text lang="en">Value greater than or equal to 0 is required</text>
            </message>
            <code proglang="python">value &gt;= 0</code>
          </ctrl>
          <argpos>6</argpos>
        </parameter>

        <parameter>
          <name>e_fragmat</name>
          <prompt lang="en">Consider only n-fragment pairs that start with two matches</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -fragmat")[ bool(value) ]</code>
          </format>
          <argpos>7</argpos>
        </parameter>

        <parameter>
          <name>e_fragsim</name>
          <prompt lang="en">Consider only p-fragment pairs if first amino acid or codon pair has similarity score of at least n (value greater than or equal to 0)</prompt>
          <type>
            <datatype>
              <class>Integer</class>
            </datatype>
          </type>
          <vdef>
            <value>4</value>
          </vdef>
          <format>
            <code proglang="python">("", " -fragsim=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <ctrl>
            <message>
              <text lang="en">Value greater than or equal to 0 is required</text>
            </message>
            <code proglang="python">value &gt;= 0</code>
          </ctrl>
          <argpos>8</argpos>
        </parameter>

        <parameter>
          <name>e_itscore</name>
          <prompt lang="en">Use iterative score</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -itscore")[ bool(value) ]</code>
          </format>
          <argpos>9</argpos>
        </parameter>

        <parameter>
          <name>e_threshold</name>
          <prompt lang="en">Threshold for considering diagonal for alignment (value greater than or equal to 0.0)</prompt>
          <type>
            <datatype>
              <class>Float</class>
            </datatype>
          </type>
          <vdef>
            <value>0.0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -threshold=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <ctrl>
            <message>
              <text lang="en">Value greater than or equal to 0.0 is required</text>
            </message>
            <code proglang="python">value &gt;= 0.0</code>
          </ctrl>
          <argpos>10</argpos>
        </parameter>
      </parameters>
    </paragraph>

    <paragraph>
      <name>e_output</name>
      <prompt lang="en">Output section</prompt>

      <parameters>

        <parameter>
          <name>e_mask</name>
          <prompt lang="en">Replace unaligned characters by stars '*' rather then putting them in lowercase</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -mask")[ bool(value) ]</code>
          </format>
          <argpos>11</argpos>
        </parameter>

        <parameter>
          <name>e_dostars</name>
          <prompt lang="en">Activate writing of stars instead of numbers</prompt>
          <type>
            <datatype>
              <class>Boolean</class>
            </datatype>
          </type>
          <vdef>
            <value>0</value>
          </vdef>
          <format>
            <code proglang="python">("", " -dostars")[ bool(value) ]</code>
          </format>
          <argpos>12</argpos>
        </parameter>

        <parameter>
          <name>e_starnum</name>
          <prompt lang="en">Put up to n stars '*' instead of digits 0-9 to indicate level of conservation (value greater than or equal to 0)</prompt>
          <type>
            <datatype>
              <class>Integer</class>
            </datatype>
          </type>
          <vdef>
            <value>4</value>
          </vdef>
          <format>
            <code proglang="python">("", " -starnum=" + str(value))[value is not None and value!=vdef]</code>
          </format>
          <ctrl>
            <message>
              <text lang="en">Value greater than or equal to 0 is required</text>
            </message>
            <code proglang="python">value &gt;= 0</code>
          </ctrl>
          <argpos>13</argpos>
        </parameter>

        <parameter>
          <name>e_outfile</name>
          <prompt lang="en">Name of the output file (e_outfile)</prompt>
          <type>
            <datatype>
              <class>Filename</class>
            </datatype>
          </type>
          <vdef>
            <value>edialign.e_outfile</value>
          </vdef>
          <format>
            <code proglang="python">("" , " -outfile=" + str(value))[value is not None]</code>
          </format>
          <argpos>14</argpos>
        </parameter>

        <parameter isout="1">
          <name>e_outfile_out</name>
          <prompt lang="en">outfile_out option</prompt>
          <type>
            <datatype>
              <class>EdialignReport</class>
              <superclass>Report</superclass>
            </datatype>
          </type>
          <filenames>
            <code proglang="python">e_outfile</code>
          </filenames>
        </parameter>

        <parameter>
          <name>e_outseq</name>
          <prompt lang="en">Name of the output sequence file (e_outseq)</prompt>
          <type>
            <datatype>
              <class>Filename</class>
            </datatype>
          </type>
          <vdef>
            <value>edialign.e_outseq</value>
          </vdef>
          <format>
            <code proglang="python">("" , " -outseq=" + str(value))[value is not None]</code>
          </format>
          <argpos>15</argpos>
        </parameter>

        <parameter isout="1">
          <name>e_outseq_out</name>
          <prompt lang="en">outseq_out option</prompt>
          <type>
            <datatype>
              <class>Text</class>
            </datatype>
          </type>
          <filenames>
            <code proglang="python">e_outseq</code>
          </filenames>
        </parameter>
      </parameters>
    </paragraph>

    <parameter ishidden="1">
      <name>auto</name>
      <prompt lang="en">Turn off any prompting</prompt>
      <type>
        <datatype>
          <class>String</class>
        </datatype>
      </type>
      <format>
        <code proglang="python">" -auto -stdout"</code>
      </format>
      <argpos>16</argpos>
    </parameter>
  </parameters>
</program>