This file is indexed.

/usr/include/ITK-4.5/itkMattesMutualInformationImageToImageMetric.h is in libinsighttoolkit4-dev 4.5.0-3.

This file is owned by root:root, with mode 0o644.

The actual contents of the file can be viewed below.

  1
  2
  3
  4
  5
  6
  7
  8
  9
 10
 11
 12
 13
 14
 15
 16
 17
 18
 19
 20
 21
 22
 23
 24
 25
 26
 27
 28
 29
 30
 31
 32
 33
 34
 35
 36
 37
 38
 39
 40
 41
 42
 43
 44
 45
 46
 47
 48
 49
 50
 51
 52
 53
 54
 55
 56
 57
 58
 59
 60
 61
 62
 63
 64
 65
 66
 67
 68
 69
 70
 71
 72
 73
 74
 75
 76
 77
 78
 79
 80
 81
 82
 83
 84
 85
 86
 87
 88
 89
 90
 91
 92
 93
 94
 95
 96
 97
 98
 99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
/*=========================================================================
 *
 *  Copyright Insight Software Consortium
 *
 *  Licensed under the Apache License, Version 2.0 (the "License");
 *  you may not use this file except in compliance with the License.
 *  You may obtain a copy of the License at
 *
 *         http://www.apache.org/licenses/LICENSE-2.0.txt
 *
 *  Unless required by applicable law or agreed to in writing, software
 *  distributed under the License is distributed on an "AS IS" BASIS,
 *  WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 *  See the License for the specific language governing permissions and
 *  limitations under the License.
 *
 *=========================================================================*/
#ifndef __itkMattesMutualInformationImageToImageMetric_h
#define __itkMattesMutualInformationImageToImageMetric_h

#include "itkImageToImageMetric.h"
#include "itkPoint.h"
#include "itkIndex.h"
#include "itkBSplineDerivativeKernelFunction.h"
#include "itkArray2D.h"

#include "itkSimpleFastMutexLock.h"


namespace itk
{
/** \class MattesMutualInformationImageToImageMetric
 * \brief Computes the mutual information between two images to be
 * registered using the method of Mattes et al.
 *
 * MattesMutualInformationImageToImageMetric computes the mutual
 * information between a fixed and moving image to be registered.
 *
 * This class is templated over the FixedImage type and the MovingImage
 * type.
 *
 * The fixed and moving images are set via methods SetFixedImage() and
 * SetMovingImage(). This metric makes use of user specified Transform and
 * Interpolator. The Transform is used to map points from the fixed image to
 * the moving image domain. The Interpolator is used to evaluate the image
 * intensity at user specified geometric points in the moving image.
 * The Transform and Interpolator are set via methods SetTransform() and
 * SetInterpolator().
 *
 * If a BSplineInterpolationFunction is used, this class obtain
 * image derivatives from the BSpline interpolator. Otherwise,
 * image derivatives are computed using central differencing.
 *
 * \warning This metric assumes that the moving image has already been
 * connected to the interpolator outside of this class.
 *
 * The method GetValue() computes of the mutual information
 * while method GetValueAndDerivative() computes
 * both the mutual information and its derivatives with respect to the
 * transform parameters.
 *
 * The calculations are based on the method of Mattes et al [1,2]
 * where the probability density distribution are estimated using
 * Parzen histograms. Since the fixed image PDF does not contribute
 * to the derivatives, it does not need to be smooth. Hence,
 * a zero order (box car) BSpline kernel is used
 * for the fixed image intensity PDF. On the other hand, to ensure
 * smoothness a third order BSpline kernel is used for the
 * moving image intensity PDF.
 *
 * On Initialize(), the FixedImage is uniformly sampled within
 * the FixedImageRegion. The number of samples used can be set
 * via SetNumberOfSpatialSamples(). Typically, the number of
 * spatial samples used should increase with the image size.
 *
 * The option UseAllPixelOn() disables the random sampling and uses
 * all the pixels of the FixedImageRegion in order to estimate the
 * joint intensity PDF.
 *
 * During each call of GetValue(), GetDerivatives(),
 * GetValueAndDerivatives(), marginal and joint intensity PDF's
 * values are estimated at discrete position or bins.
 * The number of bins used can be set via SetNumberOfHistogramBins().
 * To handle data with arbitray magnitude and dynamic range,
 * the image intensity is scale such that any contribution to the
 * histogram will fall into a valid bin.
 *
 * One the PDF's have been contructed, the mutual information
 * is obtained by doubling summing over the discrete PDF values.
 *
 *
 * Notes:
 * 1. This class returns the negative mutual information value.
 * 2. This class in not thread safe due the private data structures
 *     used to the store the sampled points and the marginal and joint pdfs.
 *
 * References:
 * [1] "Nonrigid multimodality image registration"
 *      D. Mattes, D. R. Haynor, H. Vesselle, T. Lewellen and W. Eubank
 *      Medical Imaging 2001: Image Processing, 2001, pp. 1609-1620.
 * [2] "PET-CT Image Registration in the Chest Using Free-form Deformations"
 *      D. Mattes, D. R. Haynor, H. Vesselle, T. Lewellen and W. Eubank
 *      IEEE Transactions in Medical Imaging. Vol.22, No.1,
        January 2003. pp.120-128.
 * [3] "Optimization of Mutual Information for MultiResolution Image
 *      Registration"
 *      P. Thevenaz and M. Unser
 *      IEEE Transactions in Image Processing, 9(12) December 2000.
 *
 * \ingroup RegistrationMetrics
 * \ingroup ITKRegistrationCommon
 */
template <typename TFixedImage, typename TMovingImage>
class MattesMutualInformationImageToImageMetric:
  public ImageToImageMetric<TFixedImage, TMovingImage>
{
public:

  /** Standard class typedefs. */
  typedef MattesMutualInformationImageToImageMetric     Self;
  typedef ImageToImageMetric<TFixedImage, TMovingImage> Superclass;
  typedef SmartPointer<Self>                            Pointer;
  typedef SmartPointer<const Self>                      ConstPointer;

  /** Method for creation through the object factory. */
  itkNewMacro(Self);

  /** Run-time type information (and related methods). */
  itkTypeMacro(MattesMutualInformationImageToImageMetric,
               ImageToImageMetric);

  /** Types inherited from Superclass. */
  typedef typename Superclass::TransformType                  TransformType;
  typedef typename Superclass::TransformPointer               TransformPointer;
  typedef typename Superclass::TransformJacobianType          TransformJacobianType;
  typedef typename Superclass::InterpolatorType               InterpolatorType;
  typedef typename Superclass::MeasureType                    MeasureType;
  typedef typename Superclass::DerivativeType                 DerivativeType;
  typedef typename Superclass::ParametersType                 ParametersType;
  typedef typename Superclass::FixedImageType                 FixedImageType;
  typedef typename Superclass::MovingImageType                MovingImageType;
  typedef typename Superclass::MovingImagePointType           MovingImagePointType;
  typedef typename Superclass::FixedImageConstPointer         FixedImageConstPointer;
  typedef typename Superclass::MovingImageConstPointer        MovingImageConstPointer;
  typedef typename Superclass::BSplineTransformWeightsType    BSplineTransformWeightsType;
  typedef typename Superclass::BSplineTransformIndexArrayType BSplineTransformIndexArrayType;

  typedef typename Superclass::CoordinateRepresentationType CoordinateRepresentationType;
  typedef typename Superclass::FixedImageSampleContainer    FixedImageSampleContainer;
  typedef typename Superclass::ImageDerivativesType         ImageDerivativesType;
  typedef typename Superclass::WeightsValueType             WeightsValueType;
  typedef typename Superclass::IndexValueType               IndexValueType;

  typedef typename FixedImageType::OffsetValueType OffsetValueType;

  /** The moving image dimension. */
  itkStaticConstMacro(MovingImageDimension, unsigned int,
                      MovingImageType::ImageDimension);

  /**
   *  Initialize the Metric by
   *  (1) making sure that all the components are present and plugged
   *      together correctly,
   *  (2) uniformly select NumberOfSpatialSamples within
   *      the FixedImageRegion, and
   *  (3) allocate memory for pdf data structures. */
  virtual void Initialize(void)
  throw ( ExceptionObject );

  /**  Get the value. */
  MeasureType GetValue(const ParametersType & parameters) const;

  /** Get the derivatives of the match measure. */
  void GetDerivative(const ParametersType & parameters, DerivativeType & Derivative) const;

  /**  Get the value and derivatives for single valued optimizers. */
  void GetValueAndDerivative(const ParametersType & parameters, MeasureType & Value, DerivativeType & Derivative) const;

/** Number of bins to used in the histogram.
  * According to Mattes et al the optimum value is 50.
   * The minimum value is 5 due to the padding required by the Parzen
   * windowing with a cubic-BSpline kernel. Note that even if the metric
   * is used on binary images, the number of bins should at least be
   * equal to five. */
  itkSetClampMacro( NumberOfHistogramBins, SizeValueType,
                    5, NumericTraits<SizeValueType>::max() );
  itkGetConstReferenceMacro(NumberOfHistogramBins, SizeValueType);

  /** This variable selects the method to be used for computing the Metric
   * derivatives with respect to the Transform parameters. Two modes of
   * computation are available. The choice between one and the other is a
   * trade-off between computation speed and memory allocations. The two modes
   * are described in detail below:
   *
   * UseExplicitPDFDerivatives = True
   * will compute the Metric derivative by first calculating the derivatives of
   * each one of the Joint PDF bins with respect to each one of the Transform
   * parameters and then accumulating these contributions in the final metric
   * derivative array by using a bin-specific weight.  The memory required for
   * storing the intermediate derivatives is a 3D array of floating point values with size
   * equals to the product of (number of histogram bins)^2 times number of
   * transform parameters. This method is well suited for Transform with a small
   * number of parameters.
   *
   * UseExplicitPDFDerivatives = False will compute the Metric derivative by
   * first computing the weights for each one of the Joint PDF bins and caching
   * them into an array. Then it will revisit each one of the PDF bins for
   * computing its weighted contribution to the full derivative array. In this
   * method an extra 2D array is used for storing the weights of each one of
   * the PDF bins. This is an array of floating point values with size equals to (number of
   * histogram bins)^2. This method is well suited for Transforms with a large
   * number of parameters, such as, BSplineTransforms. */
  itkSetMacro(UseExplicitPDFDerivatives, bool);
  itkGetConstReferenceMacro(UseExplicitPDFDerivatives, bool);
  itkBooleanMacro(UseExplicitPDFDerivatives);

  /** The marginal PDFs are stored as std::vector. */
  typedef double PDFValueType; //NOTE:  floating point precision is not as stable.  Double precision proves faster and more robust in real-world testing.

  /** Typedef for the joint PDF and PDF derivatives are stored as ITK Images. */
  typedef Image<PDFValueType, 2> JointPDFType;
  typedef Image<PDFValueType, 3> JointPDFDerivativesType;

  /**
   * Get the internal JointPDF image that was used in
   * creating the metric value.
   */
  const typename JointPDFType::Pointer GetJointPDF () const
    {
    if( this->m_MMIMetricPerThreadVariables == NULL )
      {
      return JointPDFType::Pointer(NULL);
      }
    return this->m_MMIMetricPerThreadVariables[0].JointPDF;
    }

  /**
   * Get the internal JointPDFDeriviative image that was used in
   * creating the metric derivative value.
   * This is only created when UseExplicitPDFDerivatives is ON, and
   * derivatives are requested.
   */
  const typename JointPDFDerivativesType::Pointer GetJointPDFDerivatives () const
    {
    if( this->m_MMIMetricPerThreadVariables == NULL )
      {
      return JointPDFDerivativesType::Pointer(NULL);
      }
    return this->m_MMIMetricPerThreadVariables[0].JointPDFDerivatives;
    }

protected:

  MattesMutualInformationImageToImageMetric();
  virtual ~MattesMutualInformationImageToImageMetric();
  void PrintSelf(std::ostream & os, Indent indent) const;

private:

  // purposely not implemented
  MattesMutualInformationImageToImageMetric(const Self &);
  // purposely not implemented
  void operator=(const Self &);

  typedef JointPDFType::IndexType             JointPDFIndexType;
  typedef JointPDFType::PixelType             JointPDFValueType;
  typedef JointPDFType::RegionType            JointPDFRegionType;
  typedef JointPDFType::SizeType              JointPDFSizeType;
  typedef JointPDFDerivativesType::IndexType  JointPDFDerivativesIndexType;
  typedef JointPDFDerivativesType::PixelType  JointPDFDerivativesValueType;
  typedef JointPDFDerivativesType::RegionType JointPDFDerivativesRegionType;
  typedef JointPDFDerivativesType::SizeType   JointPDFDerivativesSizeType;

  /** Typedefs for BSpline kernel and derivative functions. */
  typedef BSplineKernelFunction<3,PDFValueType>           CubicBSplineFunctionType;
  typedef BSplineDerivativeKernelFunction<3,PDFValueType> CubicBSplineDerivativeFunctionType;

  /** Precompute fixed image parzen window indices. */
  void ComputeFixedImageParzenWindowIndices( FixedImageSampleContainer & samples);

  /** Compute PDF derivative contribution for each parameter. */
  void ComputePDFDerivatives(ThreadIdType threadID, unsigned int sampleNumber, int movingImageParzenWindowIndex,
                                     const ImageDerivativesType
                                     &  movingImageGradientValue,
                                     PDFValueType cubicBSplineDerivativeValue) const;

  virtual void GetValueThreadPreProcess(ThreadIdType threadID, bool withinSampleThread) const;
  virtual void GetValueThreadPostProcess(ThreadIdType threadID, bool withinSampleThread) const;
  //NOTE:  The signature in base class requires that movingImageValue is of type double
  virtual bool GetValueThreadProcessSample(ThreadIdType threadID, SizeValueType fixedImageSample,
                                                  const MovingImagePointType & mappedPoint,
                                                  double movingImageValue) const;

  virtual void GetValueAndDerivativeThreadPreProcess( ThreadIdType threadID, bool withinSampleThread) const;
  virtual void GetValueAndDerivativeThreadPostProcess( ThreadIdType threadID, bool withinSampleThread) const;
  //NOTE:  The signature in base class requires that movingImageValue is of type double
  virtual bool GetValueAndDerivativeThreadProcessSample(ThreadIdType threadID, SizeValueType fixedImageSample,
                                                               const MovingImagePointType & mappedPoint,
                                                               double movingImageValue, const ImageDerivativesType &
                                                               movingImageGradientValue) const;

  /** Variables to define the marginal and joint histograms. */
  SizeValueType m_NumberOfHistogramBins;
  PDFValueType  m_MovingImageNormalizedMin;
  PDFValueType  m_FixedImageNormalizedMin;
  PDFValueType  m_FixedImageTrueMin;
  PDFValueType  m_FixedImageTrueMax;
  PDFValueType  m_MovingImageTrueMin;
  PDFValueType  m_MovingImageTrueMax;
  PDFValueType  m_FixedImageBinSize;
  PDFValueType  m_MovingImageBinSize;

  /** Cubic BSpline kernel for computing Parzen histograms. */
  typename CubicBSplineFunctionType::Pointer           m_CubicBSplineKernel;
  typename CubicBSplineDerivativeFunctionType::Pointer m_CubicBSplineDerivativeKernel;

  /** Helper array for storing the values of the JointPDF ratios. */
  typedef PDFValueType        PRatioType;
  typedef Array2D<PRatioType> PRatioArrayType;

  mutable PRatioArrayType m_PRatioArray;

  /** The moving image marginal PDF. */
  typedef std::vector< PDFValueType > MarginalPDFType;
  mutable MarginalPDFType             m_MovingImageMarginalPDF;

  struct MMIMetricPerThreadStruct
  {
    int JointPDFStartBin;
    int JointPDFEndBin;

    PDFValueType JointPDFSum;

    /** Helper variable for accumulating the derivative of the metric. */
    DerivativeType MetricDerivative;

    /** The joint PDF and PDF derivatives. */
    typename JointPDFType::Pointer            JointPDF;
    typename JointPDFDerivativesType::Pointer JointPDFDerivatives;

    typename TransformType::JacobianType Jacobian;

    MarginalPDFType FixedImageMarginalPDF;
  };

#if !defined(__GCCXML__)
  itkPadStruct( ITK_CACHE_LINE_ALIGNMENT, MMIMetricPerThreadStruct,
                                            PaddedMMIMetricPerThreadStruct);
  itkAlignedTypedef( ITK_CACHE_LINE_ALIGNMENT, PaddedMMIMetricPerThreadStruct,
                                               AlignedMMIMetricPerThreadStruct );
  // Due to a bug in older version of Visual Studio where std::vector resize
  // uses a value instead of a const reference, this must be a pointer.
  // See
  //   http://thetweaker.wordpress.com/2010/05/05/stdvector-of-aligned-elements/
  //   http://connect.microsoft.com/VisualStudio/feedback/details/692988
  mutable AlignedMMIMetricPerThreadStruct * m_MMIMetricPerThreadVariables;
#endif

  bool         m_UseExplicitPDFDerivatives;
  mutable bool m_ImplicitDerivativesSecondPass;
};
} // end namespace itk

#ifndef ITK_MANUAL_INSTANTIATION
#include "itkMattesMutualInformationImageToImageMetric.hxx"
#endif

#endif