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>     1== M63632   1 Lampetra japonica rhodopsin <>[BBRC174,1125-1132'91]
MNG---------------------------------------------------------
-TE--GDNFYVPF-----------------SNKTGLARSPYEYPQ---------Y-YLAE
PWK---------YSALAAYMFFLILVGFPVNFLTLFVTVQHKKLRTPLNYILLNLAMANL
FMVLFGF-TVTMYTS-MN-GYFV--FGPTMCSIEGFFATLGGEVALWSLVVLAIERYIVI
CKPMGNF-RFGNTHAIMGVAFTWIMALAC-AAPPLVG-W-----SRYIPEGMQCSCGPDY
YTLNPNFNNESYVVYMFVVHFLVPFVIIFFCYGRLLCTV----KE---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAAQQ---------------------------------ESASTQKAEKEVTRMVVLMVIG
FLVCWVPYASVAFYIFT-HQGS--DFGATFMTLPAFFAKSSALYNPVIYILMNKQFRNCM
ITTLCC-------GKNPLGD-DE---SGASTSKT------------------------EV
SSVS--------------------------------------------------------
------TSPVSP-A---
>     2== U22180   1 rat opsin <rod>[J.Mol.Neurosci.5(3),207-209'94]
MNG---------------------------------------------------------
-TE--GPNFYVPF-----------------SNITGVVRSPFEQPQ---------Y-YLAE
PWQ---------FSMLAAYMFLLIVLGFPINFLTLYVTVQHKKLRTPLNYILLNLAVADL
FMVFGGF-TTTLYTS-LH-GYFV--FGPTGCNLEGFFATLGGEIGLWSLVVLAIERYVVV
CKPMSNF-RFGENHAIMGVAFTWVMALAC-AAPPLVG-W-----SRYIPEGMQCSCGIDY
YTLKPEVNNESFVIYMFVVHFTIPMIVIFFCYGQLVFTV----KE---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAQQQ---------------------------------ESATTQKAEKEVTRMVIIMVIF
FLICWLPYASVAMYIFT-HQGS--NFGPIFMTLPAFFAKTASIYNPIIYIMMNKQFRNCM
LTSLCC-------GKNPLGD-DE---ASATASKT------------------------E-
------------------------------------------------------------
------TSQVAP-A---
>     3== M92038   1 chicken green sensitive cone opsin <retina>[PNAS89,5932-5936'9
MNG---------------------------------------------------------
-TE--GINFYVPM-----------------SNKTGVVRSPFEYPQ---------Y-YLAE
PWK---------YRLVCCYIFFLISTGLPINLLTLLVTFKHKKLRQPLNYILVNLAVADL
FMACFGF-TVTFYTA-WN-GYFV--FGPVGCAVEGFFATLGGQVALWSLVVLAIERYIVV
CKPMGNF-RFSATHAMMGIAFTWVMAFSC-AAPPLFG-W-----SRYMPEGMQCSCGPDY
YTHNPDYHNESYVLYMFVIHFIIPVVVIFFSYGRLICKV----RE---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAQQQ---------------------------------ESATTQKAEKEVTRMVILMVLG
FMLAWTPYAVVAFWIFT-NKGA--DFTATLMAVPAFFSKSSSLYNPIIYVLMNKQFRNCM
ITTICC-------GKNPFGD-EDV-SSTVSQSKT------------------------EV
SSVS--------------------------------------------------------
------SSQVSP-A---
>     4=p A45229 opsin, green-sensitive (clone GFgr-1) - goldfish
MNG---------------------------------------------------------
-TE--GKNFYVPM-----------------SNRTGLVRSPFEYPQ---------Y-YLAE
PWQ---------FKILALYLFFLMSMGLPINGLTLVVTAQHKKLRQPLNFILVNLAVAGT
IMVCFGF-TVTFYTA-IN-GYFV--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVV
CKPMGSF-KFSSSHAFAGIAFTWVMALAC-AAPPLFG-W-----SRYIPEGMQCSCGPDY
YTLNPDYNNESYVIYMFVCHFILPVAVIFFTYGRLVCTV----KA---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAQQQ---------------------------------DSASTQKAEREVTKMVILMVFG
FLIAWTPYATVAAWIFF-NKGA--DFSAKFMAIPAFFSKSSALYNPVIYVLLNKQFRNCM
LTTIFC-------GKNPLGD-DE--SSTVSTSKT------------------------EV
SS----------------------------------------------------------
---------VSP-A---
>     5=p B45229 opsin, green-sensitive (clone GFgr-2) - goldfish
MNG---------------------------------------------------------
-TE--GNNFYVPL-----------------SNRTGLVRSPFEYPQ---------Y-YLAE
PWQ---------FKLLAVYMFFLICLGLPINGLTLICTAQHKKLRQPLNFILVNLAVAGA
IMVCFGF-TVTFYTA-IN-GYFA--LGPTGCAVEGFMATLGGEVALWSLVVLAIERYIVV
CKPMGSF-KFSSTHASAGIAFTWVMAMAC-AAPPLVG-W-----SRYIPEGIQCSCGPDY
YTLNPEYNNESYVLYMFICHFILPVTIIFFTYGRLVCTV----KA---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAQQQ---------------------------------DSASTQKAEREVTKMVILMVLG
FLVAWTPYATVAAWIFF-NKGA--AFSAQFMAIPAFFSKTSALYNPVIYVLLNKQFRSCM
LTTLFC-------GKNPLGD-EE--SSTVSTSKT------------------------EV
SS----------------------------------------------------------
---------VSP-A---
>     6== L11864   1 Carassius auratus blue cone opsin <retina>[Biochemistry32,208-
MKQ---------------------------------------------------------
-VPEFHEDFYIPIP-------------LDINNLS--AYSPFLVPQ---------D-HLGN
QGI---------FMAMSVFMFFIFIGGASINILTILCTIQFKKLRSHLNYILVNLSIANL
FVAIFGS-PLSFYSF-FN-RYFI--FGATACKIEGFLATLGGMVGLWSLAVVAFERWLVI
CKPLGNF-TFKTPHAIAGCILPWISALAA-SLPPLFG-W-----SRYIPEGLQCSCGPDW
YTTNNKYNNESYVMFLFCFCFAVPFGTIVFCYGQLLITL----KL---------------
------------------------------------------------------------
-----------------------------------------------------------A
AKAQA---------------------------------DSASTQKAEREVTKMVVVMVLG
FLVCWAPYASFSLWIVS-HRGE--EFDLRMATIPSCLSKASTVYNPVIYVLMNKQFRSCM
M-KMVC-------GKN-IEE-DE---ASTSSQVT------------------------QV
SS----------------------------------------------------------
---------VAPEK---
>     7== M13299   1 human BCP <>[Science232(4747),193-202'86]
MRK---------------------------------------------------------
-MS--EEEFYL------------------FKNISSV--GPWDGPQ---------Y-HIAP
VWA---------FYLQAAFMGTVFLIGFPLNAMVLVATLRYKKLRQPLNYILVNVSFGGF
LLCIFSV-FPVFVAS-CN-GYFV--FGRHVCALEGFLGTVAGLVTGWSLAFLAFERYIVI
CKPFGNF-RFSSKHALTVVLATWTIGIGV-SIPPFFG-W-----SRFIPEGLQCSCGPDW
YTVGTKYRSESYTWFLFIFCFIVPLSLICFSYTQLLRAL----KA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AAQQQ---------------------------------ESATTQKAEREVSRMVVVMVGS
FCVCYVPYAAFAMYMVN-NRNH--GLDLRLVTIPSFFSKSACIYNPIIYCFMNKQFQACI
M-KMVC-------GKA-MTD-ES---DTCSSQKT------------------------EV
STVS--------------------------------------------------------
------STQVGP-N---
>     8=opsin, greensensitive  human (fragment) S07060
------------------------------------------------------------
------------------------------------------------------------
----------------------------------------------------------DL
AETVIAS-TISIVNQ-VS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVV
CKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDV
FSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AKQQK---------------------------------ESESTQKAEKEVTRMVVVMVLA
FC----------------------------------------------------------
------------------------------------------------------------
------------------------------------------------------------
-----------------
>     9== K03494   1 human GCP <>[Science232(4747),193-202'86]
MAQQWSLQRLA---------------------------------------GRHPQDSYED
STQ--SSIFTYTN-----------------SNST---RGPFEGPN---------Y-HIAP
RWV---------YHLTSVWMIFVVIASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADL
AETVIAS-TISVVNQ-VY-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWMVV
CKPFGNV-RFDAKLAIVGIAFSWIWAAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDV
FSGSSYPGVQSYMIVLMVTCCITPLSIIVLCYLQVWLAI----RA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AKQQK---------------------------------ESESTQKAEKEVTRMVVVMVLA
FCFCWGPYAFFACFAAA-NPGY--PFHPLMAALPAFFAKSATIYNPVIYVFMNRQFRNCI
LQLF---------GKK-VDD-GS---ELSSASKT------------------------EV
SSV---------------------------------------------------------
-------SSVSP-A---
>    10== Z68193   1 human Red Opsin <>[]
MAQQWSLQRLA---------------------------------------GRHPQDSYED
STQ--SSIFTYTN-----------------SNST---RGPFEGPN---------Y-HIAP
RWV---------YHLTSVWMIFVVTASVFTNGLVLAATMKFKKLRHPLNWILVNLAVADL
AETVIAS-TISIVNQ-VS-GYFV--LGHPMCVLEGYTVSLCGITGLWSLAIISWERWLVV
CKPFGNV-RFDAKLAIVGIAFSWIWSAVW-TAPPIFG-W-----SRYWPHGLKTSCGPDV
FSGSSYPGVQSYMIVLMVTCCIIPLAIIMLCYLQVWLAI----RA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AKQQK---------------------------------ESESTQKAEKEVTRMVVVMIFA
YCVCWGPYTFFACFAAA-NPGY--AFHPLMAALPAYFAKSATIYNPVIYVFMNRQFRNCI
LQLF---------GKK-VDD-GS---ELSSASKT------------------------EV
SSV---------------------------------------------------------
-------SSVSP-A---
>    11== M92036   1 Gecko gecko P521 <retina>[PNAS89,6841-6845'92]
MTEAWNVAVFA---------------------------------------ARRSRDD-DD
TTR--GSVFTYTN-----------------TNNT---RGPFEGPN---------Y-HIAP
RWV---------YNLVSFFMIIVVIASCFTNGLVLVATAKFKKLRHPLNWILVNLAFVDL
VETLVAS-TISVFNQ-IF-GYFI--LGHPLCVIEGYVVSSCGITGLWSLAIISWERWFVV
CKPFGNI-KFDSKLAIIGIVFSWVWAWGW-SAPPIFG-W-----SRYWPHGLKTSCGPDV
FSGSVELGCQSFMLTLMITCCFLPLFIIIVCYLQVWMAI----RA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AAQQK---------------------------------ESESTQKAEREVSRMVVVMIVA
FCICWGPYASFVSFAAA-NPGY--AFHPLAAALPAYFAKSATIYNPVIYVFMNRQFRNCI
MQLF---------GKK-VDD-GS---EASTTSRT------------------------EV
SSVS--------------------------------------------------------
------NSSVAP-A---
>    12== M62903   1 chicken visual pigment <>[BBRC173,1212-1217'90]
MAA-WEAAFAA---------------------------------------RRRHEE--ED
TTR--DSVFTYTN-----------------SNNT---RGPFEGPN---------Y-HIAP
RWV---------YNLTSVWMIFVVAASVFTNGLVLVATWKFKKLRHPLNWILVNLAVADL
GETVIAS-TISVINQ-IS-GYFI--LGHPMCVVEGYTVSACGITALWSLAIISWERWFVV
CKPFGNI-KFDGKLAVAGILFSWLWSCAW-TAPPIFG-W-----SRYWPHGLKTSCGPDV
FSGSSDPGVQSYMVVLMVTCCFFPLAIIILCYLQVWLAI----RA---------------
------------------------------------------------------------
-----------------------------------------------------------V
AAQQK---------------------------------ESESTQKAEKEVSRMVVVMIVA
YCFCWGPYTFFACFAAA-NPGY--AFHPLAAALPAYFAKSATIYNPIIYVFMNRQFRNCI
LQLF---------GKK-VDD-GS---EVST-SRT------------------------EV
SSVS--------------------------------------------------------
------NSSVSP-A---
>    13== S75720   1 chicken P-opsin <>[Science267(5203),1502-1506'95]
MS--------------------------------------------------------SN
SSQ--AP-----------------------PNGT---PGPFDGPQ---------WPYQAP
QST---------YVGVAVLMGTVVACASVVNGLVIVVSICYKKLRSPLNYILVNLAVADL
LVTLCGS-SVSLSNN-IN-GFFV--FGRRMCELEGFMVSLTGIVGLWSLAILALERYVVV
CKPLGDF-QFQRRHAVSGCAFTWGWALLW-SAPPLLG-W-----SSYVPEGLRTSCGPNW
YTGGSNN--NSYILSLFVTCFVLPLSLILFSYTNLLLTL----RA---------------
------------------------------------------------------------
-----------------------------------------------------------A
AAQQK---------------------------------EADTTQRAEREVTRMVIVMVMA
FLLCWLPYSTFALVVAT-HKGI--IIQPVLASLPSYFSKTATVYNPIIYVFMNKQFQSCL
LEMLCC----GYQPQR-TGK-AS---PGTPGPHA------------------------DV
TAAG--------------------------------------------------------
-----LRNKVMP-AHPV
>    14== M17718   1 D.melanogaster Rh3 <>[J.Neurosci.7,1550-1557'87]
MESGNV-----------------------------------------------SSSLFGN
VSTALRPEARLSA---------ETRLLGW--------NVPPEELR-----------HIPE
HWLTYPEPPESMNYLLGTLYIFFTLMSMLGNGLVIWVFSAAKSLRTPSNILVINLAFCDF
-MMMVKT-PIFIYNS-FH-QGYA--LGHLGCQIFGIIGSYTGIAAGATNAFIAYDRFNVI
TRPMEGK--MTHGKAIAMIIFIYMYATPW-VVACYTETW-----GRFVPEGYLTSCTFDY
LT--DNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------L
RDQAKK--------------------MNVESL---RSNVDKNKETAEIRIAKAAITICFL
FFCSWTPYGVMSLIGAF-GDKT--LLTPGATMIPACACKMVACIDPFVYAISHPRYRMEL
QKRCPW----LALNEKAPES--SAVASTSTTQEP------------------------QQ
T-----------------------------------------------------------
----------TA-A---
>    15== X65879   1 Drosophila pseudoobscura Dpse\Rh3 <>[Genetics132(1),193-204'92
MEYHNV-----------------------------------------------SSVL-GN
VSSVLRPDARLSA---------ESRLLGW--------NVPPDELR-----------HIPE
HWLIYPEPPESMNYLLGTLYIFFTVISMIGNGLVMWVFSAAKSLRTPSNILVINLAFCDF
-MMMIKT-PIFIYNS-FH-QGYA--LGHLGCQIFGVIGSYTGIAAGATNAFIAYDRYNVI
TRPMEGK--MTHGKAIAMIIFIYLYATPW-VVACYTESW-----GRFVPEGYLTSCTFDY
LT--DNFDTRLFVACIFFFSFVCPTTMITYYYSQIVGHVFSHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------L
RDQAKK--------------------MNVDSL---RSNVDKSKEAAEIRIAKAAITICFL
FFASWTPYGVMSLIGAF-GDKT--LLTPGATMIPACTCKMVACIDPFVYAISHPRYRMEL
QKRCPW----LAISEKAPES--RAAISTSTTQEQ------------------------QQ
T-----------------------------------------------------------
----------TA-A---
>    16== M17730   1 D.melanogaster Rh4 opsin <>[J.Neurosci.7,1558-1566'87]
ME-----------------------------------------------------PLCNA
SEPPLRPEAR-SSG------NGDLQFLGW--------NVPPDQIQ-----------YIPE
HWLTQLEPPASMHYMLGVFYIFLFCASTVGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDL
-IMCLKA-PIF--NS-FH-RGFAIYLGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVI
TKPMNRN--MTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDY
LS--DNFDTRLFVGTIFFFSFVCPTLMILYYYSQIVGHVFSHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------L
REQAKK--------------------MNVESL---RSNVDKSKETAEIRIAKAAITICFL
FFVSWTPYGVMSLIGAF-GDKS--LLTQGATMIPACTCKLVACIDPFVYAISHPRYRLEL
QKRCPW----LGVNEKSGEI--SSAQST-TTQEQ------------------------QQ
T-----------------------------------------------------------
----------TA-A---
>    17== X65880   1 Drosophila pseudoobscura Dpse\Rh4 <>[Genetics132(1),193-204'92
MD-----------------------------------------------------ALCNA
SEPPLRPEARMSSG------SDELQFLGW--------NVPPDQIQ-----------YIPE
HWLTQLEPPASMHYMLGVFYIFLFFASTLGNGMVIWIFSTSKSLRTPSNMFVLNLAVFDL
-IMCLKA-PIFIYNS-FH-RGFA--LGNTWCQIFASIGSYSGIGAGMTNAAIGYDRYNVI
TKPMNRN--MTFTKAVIMNIIIWLYCTPW-VVLPLTQFW-----DRFVPEGYLTSCSFDY
LS--DNFDTRLFVGTIFLFSFVVPTLMILYYYSQIVGHVFNHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------L
REQAKK--------------------MNVESL---RSNVDKSKETAEIRIAKAAITICFL
FFVSWTPYGVMSLIGAF-GDKS--LLTPGATMIPACTCKLVACIEPFVYAISHPRYRMEL
QKRCPW----LGVNEKSGEA--SSAQST-TTQEQ-----------------------TQQ
T-----------------------------------------------------------
----------SA-A---
>    18== D50584   1 Hemigrapsus sanguineus opsin BcRh2 <compound eye>[J.Exp.Biol.1
MT----------------------------------------------------------
--NATGPQMAYYGA------ASMD-F-GYPEGVSIVDFVRPEIKP-----------YVHQ
HWYNYPPVNPMWHYLLGVIYLFLGTVSIFGNGLVIYLFNKSAALRTPANILVVNLALSDL
IMLTTNV-PFFTYNC-FSGGVWM--FSPQYCEIYACLGAITGVCSIWLLCMISFDRYNII
CNGFNGP-KLTTGKAVVFALISWVIAIGC-ALPPFFG-W-----GNYILEGILDSCSYDY
LT--QDFNTFSYNIFIFVFDYFLPAAIIVFSYVFIVKAIFAHEAA---------------
------------------------------------------------------------
-----------------------------------------------------------M
RAQAKK--------------------MNVSTL---RS-NEADAQRAEIRIAKTALVNVSL
WFICWTPYALISLKGVM-GDTS--GITPLVSTLPALLAKSCSCYNPFVYAISHPKYRLAI
TQHLPW----FCVHETETKS-NDDSQSNSTVAQ---------------------------
------------------------------------------------------------
----------DK-A---
>    19== D50583   1 Hemigrapsus sanguineus opsin BcRh1 <compound eye>[J.Exp.Biol.1
MA----------------------------------------------------------
--NVTGPQMAFYGS------GAAT-F-GYPEGMTVADFVPDRVKH-----------MVLD
HWYNYPPVNPMWHYLLGVVYLFLGVISIAGNGLVIYLYMKSQALKTPANMLIVNLALSDL
IMLTTNF-PPFCYNC-FSGGRWM--FSGTYCEIYAALGAITGVCSIWTLCMISFDRYNII
CNGFNGP-KLTQGKATFMCGLAWVISVGW-SLPPFFG-W-----GSYTLEGILDSCSYDY
FT--RDMNTITYNICIFIFDFFLPASVIVFSYVFIVKAIFAHEAA---------------
------------------------------------------------------------
-----------------------------------------------------------M
RAQAKK--------------------MNVTNL---RS-NEAETQRAEIRIAKTALVNVSL
WFICWTPYAAITIQGLL-GNAE--GITPLLTTLPALLAKSCSCYNPFVYAISHPKFRLAI
TQHLPW----FCVHEKDPND-VEENQSSNTQTQ---------------------------
------------------------------------------------------------
----------EK-S---
>    20== K02320   1 D.melanogaster opsin <>[Cell40,851-858'85]
ME------------------------------------------------------SFAV
AAAQLGPHFAPLS------------------NGSVVDKVTPDMAH-----------LISP
YWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDF
GIMITNT-PMMGINL-YF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVI
VKGMAGR-PMTIPLALGKM---------------------------YVPEGNLTSCGIDY
LE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------M
REQAKK--------------------MNVKSL---RS-SEDAEKSAEGKLAKVALVTITL
WFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLAL
KEKCPC----CVFGKVDDGK-SSDAQSQATASEA------------------------E-
------------------------------------------------------------
----------SK-A---
>    21== K02315   1 D.melanogaster ninaE <>[Cell40,839-850'85]
ME------------------------------------------------------SFAV
AAAQLGPHFAPLS------------------NGSVVDKVTPDMAH-----------LISP
YWNQFPAMDPIWAKILTAYMIMIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDF
GIMITNT-PMMGINL-YF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVI
VKGMAGR-PMTIPLALGKIAYIWFMSSIW-CLAPAFG-W-----SRYVPEGNLTSCGIDY
LE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------M
REQAKK--------------------MNVKSL---RS-SEDAEKSAEGKLAKVALVTITL
WFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLAL
KEKCPC----CVFGKVDDGK-SSDAQSQATASEA------------------------E-
------------------------------------------------------------
----------SK-A---
>    22== X65877   1 Drosophila pseudoobscura Dpse\ninaE <>[Genetics132(1),193-204'
MD------------------------------------------------------SFAA
VATQLGPQFAAPS------------------NGSVVDKVTPDMAH-----------LISP
YWDQFPAMDPIWAKILTAYMIIIGMISWCGNGVVIYIFATTKSLRTPANLLVINLAISDF
GIMITNT-PMMGINL-YF-ETWV--LGPMMCDIYAGLGSAFGCSSIWSMCMISLDRYQVI
VKGMAGR-PMTIPLALGKIAYIWFMSTIWCCLAPVFG-W-----SRYVPEGNLTSCGIDY
LE--RDWNPRSYLIFYSIFVYYIPLFLICYSYWFIIAAVSAHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------M
REQAKK--------------------MNVKSL---RS-SEDADKSAEGKLAKVALVTISL
WFMAWTPYLVINCMGLF-KF-E--GLTPLNTIWGACFAKSAACYNPIVYGISHPKYRLAL
KEKCPC----CVFGKVDDGK-SSEAQSQATTSEA------------------------E-
------------------------------------------------------------
----------SK-A---
>    23== M12896   1 D.melanogaster Rh2 <>[Cell44,705-710'86]
MERSHL-------------------------------------------------PETPF
DLAHSGPRFQAQSS------G----------NGSVLDNVLPDMAH-----------LVNP
YWSRFAPMDPMMSKILGLFTLAIMIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDF
CMMASQS-PVMIINF-YY-ETWV--LGPLWCDIYAGCGSLFGCVSIWSMCMIAFDRYNVI
VKGINGT-PMTIKTSIMKILFIWMMAVFW-TVMPLIG-W-----SAYVPEGNLTACSIDY
MT--RMWNPRSYLITYSLFVYYTPLFLICYSYWFIIAAVAAHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------M
REQAKK--------------------MNVKSL---RS-SEDCDKSAEGKLAKVALTTISL
WFMAWTPYLVICYFGLF-KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISHPKYRIVL
KEKCPM----CVFGNTDEPKPDAPASDTETTSEA------------------------D-
------------------------------------------------------------
----------SK-A---
>    24== X65878   1 Drosophila pseudoobscura Dpse\Rh2 <>[Genetics132(1),193-204'92
MERSLL-------------------------------------------------PEPPL
AMALLGPRFEAQTG------G----------NRSVLDNVLPDMAP-----------LVNP
HWSRFAPMDPTMSKILGLFTLVILIISCCGNGVVVYIFGGTKSLRTPANLLVLNLAFSDF
CMMASQS-PVMIINF-YY-ETWV--LGPLWCDIYAACGSLFGCVSIWSMCMIAFDRYNVI
VKGINGT-PMTIKTSIMKIAFIWMMAVFW-TIMPLIG-W-----SSYVPEGNLTACSIDY
MT--RQWNPRSYLITYSLFVYYTPLFMICYSYWFIIATVAAHEKA---------------
------------------------------------------------------------
-----------------------------------------------------------M
RDQAKK--------------------MNVKSL---RS-SEDCDKSAENKLAKVALTTISL
WFMAWTPYLIICYFGLF-KI-D--GLTPLTTIWGATFAKTSAVYNPIVYGISHPNDRLVL
KEKCPM----CVCGTTDEPKPDAPPSDTETTSEA------------------------E-
------------------------------------------------------------
----------SK-D---
>    25== U26026   1 Apis mellifera long-wavelength rhodopsin <>[]
MI----------------------------------------------------------
--AVSGPSYEAFSY------GGQARF----NNQTVVDKVPPDMLH-----------LIDA
NWYQYPPLNPMWHGILGFVIGMLGFVSAMGNGMVVYIFLSTKSLRTPSNLFVINLAISNF
LMMFCMS-PPMVINC-YY-ETWV--LGPLFCQIYAMLGSLFGCGSIWTMTMIAFDRYNVI
VKGLSGK-PLSINGALIRIIAIWLFSLGW-TIAPMFG-W-----NRYVPEGNMTACGTDY
FN--RGLLSASYLVCYGIWVYFVPLFLIIYSYWFIIQAVAAHEKN---------------
------------------------------------------------------------
-----------------------------------------------------------M
REQAKK--------------------MNVASL---RS-SENQNTSAECKLAKVALMTISL
WFMAWTPYLVINFSGIF-NL-V--KISPLFTIWGSLFAKANAVYNPIVYGISHPKYRAAL
FAKFPS----LAC-AAEPSS-DAVSTTSGTTTVT------------------------DN
EK----------------------------------------------------------
----------SN-A---
>    26== L03781   1 Limulus polyphemus opsin <>[PNAS90,6150-6154'93]
M-----------------------------------------------------------
---ANQLSYSSLGW------PYQP-------NASVVDTMPKEMLY-----------MIHE
HWYAFPPMNPLWYSILGVAMIILGIICVLGNGMVIYLMMTTKSLRTPTNLLVVNLAFSDF
CMMAFMM-PTMTSNC-FA-ETWI--LGPFMCEVYGMAGSLFGCASIWSMVMITLDRYNVI
VRGMAAA-PLTHKKATLLLLFVWIWSGGW-TILPFFG-W-----SRYVPEGNLTSCTVDY
LT--KDWSSASYVVIYGLAVYFLPLITMIYCYFFIVHAVAEHEKQ---------------
------------------------------------------------------------
-----------------------------------------------------------L
REQAKK--------------------MNVASL---RANADQQKQSAECRLAKVAMMTVGL
WFMAWTPYLIISWAGVF-SSGT--RLTPLATIWGSVFAKANSCYNPIVYGISHPRYKAAL
YQRFPS----LACGSGESGS-DVKSEASATTTME------------------------EK
PK----------------------------------------------------------
---------IPE-A---
>    27== X07797   1 Octopus dofleini rhodopsin <>[FEBS232(1),69-72'88]
MVESTTL--------------------------------------------VNQ------
---------------------------TWWYNPTVD---------------------IHP
HWAKFDPIPDAVYYSVGIFIGVVGIIGILGNGVVIYLFSKTKSLQTPANMFIINLAMSDL
SFSAINGFPLKTISA-FM-KKWI--FGKVACQLYGLLGGIFGFMSINTMAMISIDRYNVI
GRPMAASKKMSHRRAFLMIIFVWMWSIVW-SVGPVFN-W-----GAYVPEGILTSCSFDY
LS--TDPSTRSFILCMYFCGFMLPIIIIAFCYFNIVMSVSNHEKE---------------
------------------------------------------------------------
-----------------------------------------------------------M
AAMAKR--------------------LNAKEL---RK--AQAGASAEMKLAKISMVIITQ
FMLSWSPYAIIALLAQF-GPAE--WVTPYAAELPVLFAKASAIHNPIVYSVSHPKFREAI
QTTFPWLLTCCQFDEKECED-ANDAEEEVVASER--GGESRDAAQMKEMMAMMQKMQAQQ
AAYQPPPPPQGY--PPQGYPPQGAYPPPQGYPPQGYPPQGYPPQGYPPQGAPPQVEAPQG
APPQGVDNQAYQ-A---
>    28== X70498   1 Todarodes pacificus rhodopsin <retina>[FEBS317(1-2),5-11'93]
MGRDLR---------------------------------------------DNE------
---------------------------TWWYNPSIV---------------------VHP
HWREFDQVPDAVYYSLGIFIGICGIIGCGGNGIVIYLFTKTKSLQTPANMFIINLAFSDF
TFSLVNGFPLMTISC-FL-KKWI--FGFAACKVYGFIGGIFGFMSIMTMAMISIDRYNVI
GRPMAASKKMSHRRAFIMIIFVWLWSVLW-AIGPIFG-W-----GAYTLEGVLCNCSFDY
IS--RDSTTRSNILCMFILGFFGPILIIFFCYFNIVMSVSNHEKE---------------
------------------------------------------------------------
-----------------------------------------------------------M
AAMAKR--------------------LNAKEL---RK--AQAGANAEMRLAKISIVIVSQ
FLLSWSPYAVVALLAQF-GPLE--WVTPYAAQLPVMFAKASAIHNPMIYSVSHPKFREAI
SQTFPWVLTCCQFDDKETED-DKDAETEIPAGESSDAAPSADAAQMKEMMAMMQKMQQQQ
AAY----PPQGYAPPPQGYPPQGY--PPQGYPPQGYPPQGYPP---PPQGAPPQ-GAPPA
APPQGVDNQAYQ-A---
>    29== L21195   1 human serotonin 5-HT7 receptor protein <placenta and fetal bra
MMDVNSSGRPDLY----GHLRSFLLP--EVGRGLPDLSPDGGADPVAGSWAPHLLS---E
VTASPAPTW----------------------------DAPPDNAS--GCGEQINY-----
--------GRVEKVVIGSILTLITLLTIAGNCLVVISVCFVKKLRQPSNYLIVSLALADL
SVAVAVM-PFVSVTDLIG-GKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI
TRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VCLIS-
-------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------------
-----PGF---------------------------------PRVEPDSVI----------
------------ALNGIVK----------------------LQKEVEECAN--------L
SRLLKH-----------------------------ER-KNISIFKREQKAATTLGIIVGA
FTVCWLPFFLLSTARPFICGTSCSCIPLWVERTFLWLGYANSLINPFIYAFFNRDLRTTY
RSLLQC--QYRNINRK---------LSAAGMHEA---------------LKLAERP--ER
PEFVLQ------------------------------------------------------
-----NADYCRKKGHDS
>    30== L15228   1 rat 5HT-7 serotonin receptor <>[JBC268,18200-18204'93]
M--------------------------------------------------PHLLSGFLE
VTASPAPTW----------------------------DAPPDNVS--GCGEQINY-----
--------GRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADL
SVAVAVM-PFVSVTDLIG-GKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI
TRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VCLIS-
-------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------------
-----PGF---------------------------------PRVQPESVI----------
------------SLNGVVK----------------------LQKEVEECAN--------L
SRLLKH-----------------------------ER-KNISIFKREQKAATTLGIIVGA
FTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRPTS
RSLLQC--QYRNINRK---------LSAAGMHEA---------------LKLAERP--ER
SEFVLQ------------------------------------------------------
-----NSDHCGKKGHDT
>    31=p A47425 serotonin receptor 5HT-7 - rat
M--------------------------------------------------PHLLSGFLE
VTASPAPTW----------------------------DAPPDNVS--GCGEQINY-----
--------GRVEKVVIGSILTLITLLTIAGNCLVVISVSFVKKLRQPSNYLIVSLALADL
SVAVAVM-PFVSVTDLIG-GKWI--FGHFFCNVFIAMDVMCCTASIMTLCVISIDRYLGI
TRPLTYPVRQNGKCMAKMILSVWLLSASI-TLPPLFG-W-----AQNVNDDK--VCLIS-
-------QDFGYTIYSTAVAFYIPMSVMLFMYYQIYKAARKSAAKHKF------------
-----PGF---------------------------------PRVQPESVI----------
------------SLNGVVK----------------------LQKEVEECAN--------L
SRLLKH-----------------------------ER-KNISIFKREQKAATTLGIIVGA
FTVCWLPFFLLSTARPFICGTSCSCIPLWVERTCLWLGYANSLINPFIYAFFNRDLRTTY
RSLLQC--QYRNINRK---------LSAAGMHEA---------------LKLAERP--ER
SEFVLQ------------------------------------------------------
-----NSDHCGKKGHDT
>    32== M83181   1 human serotonin receptor <>[JBC267(11),7553-7562'92]
M-DVLSPGQ--------GNNTTSPPAPFETGGNTTGI-----------------------
--SDVTVSY---------------------------------------------------
------------QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL
MVSVLVL-PMAALYQ-VL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAI
TDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP--EDRSDPD---ACTIS-
-------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK---------------
------------------------TVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWR
LGVESKAGGAL-CANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAP-----
ASFERK-----------NERNA-------------EA-KRKMALARERKTVKTLGIIMGT
FILCWLPFFIVALVLPF-CESSC-HMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAF
KKIIKC--KFCR------------------------------------------------
------------------------------------------------------------
----------------Q
>    33=p A35181 serotonin receptor class 1A - rat
M-DVFSFGQ--------GNNTTASQEPFGTGGNVTSI-----------------------
--SDVTFSY---------------------------------------------------
------------QVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDL
MVSVLVL-PMAALYQ-VL-NKWT--LGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAI
TDPIDYVNKRTPRRAAALISLTWLIGFLI-SIPPMLG-WRTP--EDRSDPD---ACTIS-
-------KDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRK---------------
------------------------TVRKVEKKGAGTSLGTSSAPPPKKSLNGQPGSGDWR
RCAENRAVGTP-CTNGAVRQGDDEATLEVIEVHRVGNSKEHLPLPSESGSNSYAP-----
ACLERK-----------NERNA-------------EA-KRKMALARERKTVKTLGIIMGT
FILCWLPFFIVALVLPF-CESSC-HMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAF
KKIIKC--KFCR------------------------------------------------
------------------------------------------------------------
----------------R
>    34== L06803   1 Lymnaea stagnalis serotonin receptor <>[PNAS90,11-15'93]
M-ANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTG------------------L
VTSDFNDSYGLTGQFINGSHSSRSR-----DNASAN-DTSATNMTDDRYWSLTVY-----
--------SHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADL
MVAVLVM-PLSVVSE-IS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAV
TS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NN--DPDKTGTCIIS-
-------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEET
TLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK------------
----NRAKKLPENANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEEAS-I
AMLERQ-CNNGKKISSNDTPYS-------------RT-REKLELKRERKAARTLAIITGA
FLICWLPFFIIALIGPF-VDPE--GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAF
QKILFG--KYRRG-----------------------------------------------
------------------------------------------------------------
---------------HR
>    35=p A47174 serotonin receptor, 5HTlym receptor - great pond snail
M-ANFTFGDLALDVARMGGLASTPSGLRSTGLTTPGLSPTG------------------L
VTSDFNDSYGLTGQFINGSHSSRSR-----DNASAN-DTSATNMTDDRYWSLTVY-----
--------SHEHLVLTSVILGLFVLCCIIGNCFVIAAVMLERSLHNVANYLILSLAVADL
MVAVLVM-PLSVVSE-IS-KVWF--LHSEVCDMWISVDVLCCTASILHLVAIAMDRYWAV
TS-IDYIRRRSARRILLMIMVVWIVALFI-SIPPLFG-WRDP--NN--DPDKTGTCIIS-
-------QDKGYTIFSTVGAFYLPMLVMMIIYIRIWLVARSRIRKDKFQMTKARLKTEET
TLVASPKTEYSVVSDCNGCNSPDSTTEKKKRRAPFKSYGCSPRPERKK------------
----NRAKKLPENANGVNSNSSSSERLKQIQIE-----------TAEAFANGCAEEAS-I
AMLERQ-CNNGKKISSNDTPYS-------------RT-REKLELKRERKAARTLAIITGA
FLICWLPFFIIALIGPF-VDPE--GIPPFARSFVLWLGYFNSLLNPIIYTIFSPEFRSAF
QKILFG--KYRRG-----------------------------------------------
------------------------------------------------------------
---------------HR
>    36== X95604   1 Bombyx mori serotonin receptor <antennae>[InsectBiochem.Mol.Bi
M-EGAE-GQEELD----WEALYLRLPLQNCSWNSTGWEPNW------------------N
VTVVPNTTW---------------------WQASAPFDTPAALVR---------------
------------AAAKAVVLGLLILATVVGNVFVIAAILLERHLRSAANNLILSLAVADL
LVACLVM-PLGAVYE-VV-QRWT--LGPELCDMWTSGDVLCCTASILHLVAIALDRYWAV
TN-IDYIHASTAKRVGMMIACVWTVSFFV-CIAQLLG-WKDPDWNQRVSEDL--RCVVS-
-------QDVGYQIFATASSFYVPVLIILILYWRIYQTARKRIRR---------------
------------------------------RRGATARGGVGPPPVP--------------
-------------AGGALVAGGGSGGIAAAVVAVIGRP---LPTISETTTTGFTNVSSNN
TSPEKQSCANGLEADPPTTGYGAVAAAYYPSLVRRKP-KEAADSKRERKAAKTLAIITGA
FVACWLPFFVLAILVPT-CDCE---VSPVLTSLSLWLGYFNSTLNPVIYTVFSPEFRHAF
QRLLCG--RRVRRRR---------------------------------------------
------------------------------------------------------------
--------------APQ